Clinical Program

Advanced Image Analysis Laboratory

Advanced post-processing

Modern CT and MRI scanners generate large amounts of data. Using this data, we are able to produce volumetric (three-dimensional) images of all parts of the body. In addition, we can analyze the images to derive clinically useful measurements and visualizations that can be used to plan surgical approaches and evaluate treatment response. Some of these visualizations allow clinicians to better visualize a patient's anatomy using only one or a few images and are important in diagnosis, treatment, and surgical planning. They convey critical information that supplements the review of hundreds of individual 2D slice images. Patients and their families can better understand the disease process and the treatment planned using these models.

At Children's, advanced post-processing has been used in:

  • Brain and Spine Imaging - vascular disease, tumor volumes, surgical planning
  • Head and Neck Imaging - craniofacial anomalies and dysmorphism
  • Cardiovascular Imaging - surgical connections
  • Thoracic Imaging - Dynamic airway studies
  • Genetics - facial dysmorphisms
  • Musculoskeletal Imaging - fractures & orthopedic hardware
  • Abdominopelvic Imaging - pre and post transplant evaluation, tumor volume measurement

The following are examples of advanced image processing performed in the lab:

  • 3D models
  • Volumetric measurements
  • Mulitimodality image fusion and overlays
  • Tractography
  • Perfusion imaging analysis

Examples

Pre- and post-treatment images in a patient with partial left coronal suture synostosis at 1 month of age. The image on the right shows normal appearance post suture release (one year post treatment).

Clarifying the diagnosis: Subtle fracture demonstrated best on the 3D model (right).

Abnormal vertebral bodies (segmentation anomalies) in a patient with scoliosis.

Dilated collecting systems and ureters (bilateral hydroureteronephrosis).

Tractography analysis from MRI DTI data.

For more information and relevant publications:

  1. Guitton TG, Ring D. Three-Dimensional Computed Tomographic Imaging and Modeling in the Upper Extremity. Hand Clin 2010 26(3):447-53.
  2. Prabhu SP, Newton A, Perez-Rosello J, Kleinman PK. 3D models rendered from Axial Head CT for Problem Solving in Cases of Suspected Child Abuse. Society of Pediatric Radiology, Boston. USA annual meeting 2010.
  3. Santiago Medina, L. Three-dimensional CT Maximum Intensity Projections of the Calvaria: A New Approach for Diagnosis of Craniosynostosis and Fractures. AJNR Am J Neuroradiol 2000; 21(10):1951-54.