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Histiocytosis is a group of rare diseases that most often affect young children, but can occur at any age. There are two main types of histiocytosis: Langerhans Cell Histiocytosis (LCH) and Hemophagocytic Lymphohistiocytosis (HLH). These diseases have in common the abnormal growth and accumulation of certain cells of the immune system. LCH and HLH differ in the type of cell that is growing abnormally and in the clinical consequences of that abnormal cell growth. The Histiocytoses are not considered to be cancers, although they can be life-threatening and chemotherapy is often required to treat them.
The two types of histiocytosis are:
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