300 Longwood Avenue Boston, MA 02115 (617) 355-6000 Clinical Services (Bone Marrow Failure Program): Symptoms Bone marrow failure symptoms vary depending on which blood cells are most affected. Too few red blood cells cause symptoms of anemia - fatigue, pale skin and shortness of breath. Insufficient white cells make the body vulnerable to infection and may be associated with fevers and chronic or recurrent infections. Platelets are responsible for clotting the blood, so diminished platelet counts can lead to bruising and bleeding. The information on this website should not be taken as medical advice, which can only be given to you by your personal health care professional. Copyright © Children's Hospital Boston. All rights reserved.