The radiopharmaceutical chemistry research program occupies two research laboratories in the Enders research building at Children's: a radiopharmaceutical chemistry laboratory and a "hot" laboratory. A separate cell-culture laboratory is also available.
The radiopharmaceutical chemistry laboratory contains four fume hoods, approximately 50 linear feet of bench space, and is set up to accommodate three postdoctoral researchers. The laboratory is equipped with various chemical instrumentation including a Bruker FTIR spectrometer, a Perkin-Elmer Lambda 40 uv-visible spectrophotometer, and a Hitachi high-performance liquid chromatograph equipped with a diode array and a gamma detector. Other smaller pieces of equipment (centrifuges, pH meters, etc.) are also available.
The hot laboratory is used for handling high levels of radioactivity and has a shielded fume hood that is equipped with a pair of Tru-Motion remote manipulator arms. This laboratory is also equipped with a semi-preparative HPLC system for purification of 18F-labeled compounds. This laboratory is scheduled for renovation in the spring of 2008. The renovation will include the addition of a hot cell suitable for the preparation of higher levels of 18F-labeled compounds than can be accommodated in the existing facility. In addition to our own basic science investigations, this laboratory is also used for the preparation of 18F-labeled compounds for use by CHB microPET users.
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The radiopharmaceutical chemistry research program of the Division of Nuclear Medicine at Children's Hospital Boston, directed by Alan B. Packard, Ph.D., is currently engaged in four active radiopharmaceutical chemistry research programs. These programs include:
