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Clinical Services (Rheumatology):
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Research
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Current clinical projects include:
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- Novel immunoregulatory treatments for children with severe arthritis and systemic lupus erythematosus who are unresponsive to routine therapies.
- The study of alternative medications and remedies for the treatment of children with rheumatologic diseases.
- Laboratory studies of the role of the immune system in mediating inflammation in skin and joints, designed to lead to novel approaches for preventing disease.
- Research into the etiology of Kawasaki disease.
- The role of antiphospholipid antibodies in post-operative cerbrovascular accidents.
- Studies of new pharmacologic and non-pharmacologic approaches to pain control in children.
- New methods of teaching musculoskeletal diagnostic skills to pediatric interns.
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In addition, Children's Hospital Boston is an active participant in the Pediatric Rheumatology Collaborative Study Group, affording opportunities to participate in national multi-center therapeutic trials; anticipated in the near future are the trials of the newest genetically engineered biologics in children with juvenile rheumatoid arthritis.
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Current laboratory-based projects include:
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- Studies of adhesion molecules and mechanisms regulating leukocyte homing to inflammatory sites.
- Research into the immune recognition of non-protein antigens.
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