300 Longwood Avenue Boston, MA 02115 (617) 355-6000 Clinical Services (Nephrology): Research Children's Hospital Boston's Division of Nephrology's Research Program is directed by Mohammed Sayegh, MD, and is involved in both basic and clinical research in transplantation biology, renal development, and nephrotic syndrome, particularly focal glomerulosclerosis and autosomal recessive polycystic disease of the kidney. Current research projects include: Mechanisms of Indirect Allorecognition and T Cell Costimulation in Acute and Chronic Rejection in Experimental Animal Models Mechanisms of Chronic Rejection in Humans The Role of T Cell Costimulation in Tolerance Induction in Transplant Rejection and Autoimmunity Mechanisms of Islet Allograft Rejection and Tolerance Angiogenesis and Chronic Rejection The Endothelium and Direct Versus Indirect Allorecognition Tolerance induction protocols in Pediatric Renal Transplantation Islet cell culture Direct and Indirect Allorecognition and Cultured Skin Acceptance VEGF Expression and the Nephrotic Syndrome Serum Cystatin C as a Marker of Glomerular Filtration Oxidant and Antioxidant Levels in Children with Chronic Renal Insufficiency and End Stage Renal Disease Vascular Permeability Factor/Vascular Endothelial Growth Factor and Childhood Nephrotic Syndrome Serum HCG Levels in Chronic Renal Insufficiency and Dialysis Prophylactic Urokinase Use in Hemodialysis Catheters Use of Amlodipine in Children with Hypertension Development of Cystic Renal Disease in Native and Transplanted Kidneys Use of Enalapril in Children with Hypertension Use of Growth Hormone in Dialysis Patients Learn more about Nephrology research at Children's... The information on this website should not be taken as medical advice, which can only be given to you by your personal health care professional. Copyright © Children's Hospital Boston. All rights reserved.