300 Longwood Avenue Boston, MA 02115 (617) 355-6000 Clinical Services (Metabolism Program): Research Children's Metabolism Program is actively engaged in groundbreaking basic science and clinical research. Below are some examples of research currently being investigated at Children's Hospital Boston: Maternal Phenylketonuria and other Maternal Inborn Errors of Metabolism and their effects on the fetus as well as treatment during pregnancy (these include Maternal Homocystinuria, Maternal Histidinemia, Maternal Cystathioninemia, etc.) Pharmacodynamics of tyrosine supplementation in Phenylketonuria Role of NTBC as ancillary treatment in Phenylketonuria to address neuropsychological deficits Phenylalanine hydroxylase genotypes and degree of hyperphenylalaninemia in non-PKU mild hyperphenylalaninemia Sulfur amino acid abnormalities in the methionine catabolic disorders: differentiating Homocystinuria, Isolated Hypermethioninemia, and Transient Hypermethioninemia in the newborn Psychosocial factors and support mechanisms in Maternal Phenylketonuria Clinical trials for enzyme replacement in lysosomal storage disease The information on this website should not be taken as medical advice, which can only be given to you by your personal health care professional. Copyright © Children's Hospital Boston. All rights reserved.