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Research |
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The Bone Health Program has been actively involved in exploring the causes and symptoms of pediatric low bone density and researching new and improved treatments. Recent research interests have included:
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- Use of Adrenal and Gonadal Hormone Replacement to Prevent Osteoporosis in Anorexia
Nervosa:
A randomized, double-blind placebo-controlled trial examining the effect of oral DHEA and
estrogen/progestin replacement on bone turnover, density and strength in patients with
anorexia nervosa.
- Effect of Calcitonin on Bone Density in Inflammatory Bowel Disease:
This double blind,
placebo-controlled trial is examining the effects of nasal calcitonin on bone density in
children with Crohn disease and ulcerative colitis.
- Randomized Trial of Alendronate in Children with Steroid-Induced Osteoporosis:
Multi-center trial testing the effects of
alendronate on BMD in children and adolescents receiving glucocorticoid therapy for
inflammatory diseases.
- Mechanisms of Bone Loss in Children Undergoing Cardiac Transplant:
This protocol
examines hormonal and other predictors of bone loss in children and adolescents who
undergo cardiac transplant.
- Prevalence of Rickets Among Healthy Infants and Toddlers:
The prevalence of both subclinical vitamin D deficiency and rickets is being determined in a
cross-sectional sample of infants and toddlers who present to Children's Hospital Boston
for primary care. The efficacy of different treatment regimens is also being evaluated.
- Congenital Adrenal Hyperplasia as a Model to Investigate the Effects of Adrenal
Androgens on the Ovary and Skeleton:
A protocol was recently completed using congenital adrenal hyperplasia as a model to
determine the effects of hyperandrogenism on menstrual function and bone density.
- Use of DHEA to Prevent Bone Loss in Cystic Fibrosis:
A randomized, double blind, placebo-controlled trial (pilot study) examining the effect of
oral DHEA on bone turnover and body composition in young men and women with cystic
fibrosis was recently completed.
- Mediators of Stress Fracture among Adolescent Girls:
This protocol examines hormonal
and lifestyle predictors that may represent risk factors for stress fracture among female
athletes.
- Effect of Bed Rest on Bone Turnover and Cardiac Function in Adolescents with Anorexia
Nervosa:
This protocol addresses the effect of immobilization via bed rest on bone
turnover in young women with anorexia nervosa.
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Research by Catherine Gordon, MD, MSc, Director of the Bone Health Program
Research by Ingrid Holm, MD, MPH, Associate Director of the Bone Health Program
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