Bone Health Program

Research and innovation

The Bone Health Program has been actively involved in exploring the causes and symptoms of pediatric low bone density and researching new and improved treatments. Recent research interests have included:

• Effect of Biomechanical Stimulation on Skeletal Health in Adolescent and Young Women with Anorexia Nervosa:
  A randomized, double-blind placebo-controlled trial to measure the healthy adolescents with anorexia nervosa.
  • U.S. National Institutes of Health Clinical Trial info
  • Children's Hospital Research info

• Effect of Hormonal Add-Back Therapy in Adolescents Treated with (GnRH) Agonist Therapy for Endometriosis:
  A randomized, double-blinded trial to measure the bones of healthy adolescents with patients with diseases, like anorexia nervosa and endometriosis can be compared.
  • U.S. National Institutes of Health Clinical Trial info
  • Children's Hospital Research info

Optimization of Vitamin D Stores and Its Impact on the Bone Health Disease Outcomes of Children and Adolescents with IBD:
Vitamin D is important for growing and maintaining healthy bones throughout this particularly important since children with IBD frequently have low bone density.

• U.S. National Institutes of Health Clinical Trial info
• Children's Hospital Research info

Use of Farnesyltransferase inhibitor (FTI) Lonafarnib for Hutchinson-Gilford Progeria Syndrome (HGPS) and progeroid laminopathies:

• This protocol measures an experimental drug's effect using many tests in hopes that this drug will have therapeutic effect on progeria.
  • Research by Catherine Gordon, MD, MSc, Director of the Bone Health Program
  • Research by Ingrid Holm, MD, MPH, Associate Director of the Bone Health Program