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Bone Health Program

 Bone Health Program
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 Adolescent Medicine
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The Bone Health Program has been actively involved in exploring the causes and symptoms of pediatric low bone density and researching new and improved treatments. Recent research interests have included:
  • Use of Adrenal and Gonadal Hormone Replacement to Prevent Osteoporosis in Anorexia Nervosa:
    A randomized, double-blind placebo-controlled trial examining the effect of oral DHEA and estrogen/progestin replacement on bone turnover, density and strength in patients with anorexia nervosa.
  • Effect of Calcitonin on Bone Density in Inflammatory Bowel Disease:
    This double blind, placebo-controlled trial is examining the effects of nasal calcitonin on bone density in children with Crohn disease and ulcerative colitis.
  • Randomized Trial of Alendronate in Children with Steroid-Induced Osteoporosis:
    Multi-center trial testing the effects of alendronate on BMD in children and adolescents receiving glucocorticoid therapy for inflammatory diseases.
  • Mechanisms of Bone Loss in Children Undergoing Cardiac Transplant:
    This protocol examines hormonal and other predictors of bone loss in children and adolescents who undergo cardiac transplant.

  • Prevalence of Rickets Among Healthy Infants and Toddlers:
    The prevalence of both subclinical vitamin D deficiency and rickets is being determined in a cross-sectional sample of infants and toddlers who present to Children's Hospital Boston for primary care. The efficacy of different treatment regimens is also being evaluated.

  • Congenital Adrenal Hyperplasia as a Model to Investigate the Effects of Adrenal Androgens on the Ovary and Skeleton:
    A protocol was recently completed using congenital adrenal hyperplasia as a model to determine the effects of hyperandrogenism on menstrual function and bone density.

  • Use of DHEA to Prevent Bone Loss in Cystic Fibrosis:
    A randomized, double blind, placebo-controlled trial (pilot study) examining the effect of oral DHEA on bone turnover and body composition in young men and women with cystic fibrosis was recently completed.

  • Mediators of Stress Fracture among Adolescent Girls:
    This protocol examines hormonal and lifestyle predictors that may represent risk factors for stress fracture among female athletes.

  • Effect of Bed Rest on Bone Turnover and Cardiac Function in Adolescents with Anorexia Nervosa:
    This protocol addresses the effect of immobilization via bed rest on bone turnover in young women with anorexia nervosa.
Research by Catherine Gordon, MD, MSc, Director of the Bone Health Program

Research by Ingrid Holm, MD, MPH, Associate Director of the Bone Health Program

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