CLARITY Undiagnosed

CLARITY—or the Children’s Leadership Award for the Reliable Interpretation and Appropriate Transmission of Your Genomic Information—was first launched in 2012. Its goal was, and remains, to provide meaningful genomic sequencing results to patients and their families—and to identify best practices for making results more reliable and useful in the clinic through improved interpretation and reporting.

A crowd-sourcing competition, the CLARITY Challenge invites medical teams from all over the world to apply genomic information to solve featured medical cases. The winning team or teams receive a modest cash prize.

The first CLARITY Challenge—CLARITY 1—was aimed at providing diagnostic information to help three families with rare disease, through a partnership of Boston Children’s Hospital’s Manton Center for Orphan Disease Research and Harvard Medical School’s Center for Biomedical Informatics (CBMI).

New CLARITY Challenge for 2015: CLARITY Undiagnosed

We are excited to announce a second CLARITY Challenge focused on five families with undiagnosed disease, identified through a documentary film currently in production titled “Undiagnosed.”

Through CLARITY Undiagnosed, we hope not only to solve diagnostic mysteries but also show the value of collaborative work, combining the best methods for genomic sequence interpretation with clinical expertise.

Submit your application now!

How the Challenge works

Applications to participate in the CLARITY Undiagnosed Challenge are due June 25, 2015, and teams selected to compete will be notified by July 2.

As in the first CLARITY Challenge, contestants in CLARITY Undiagnosed will receive genomic sequence data for each patient and his or her family. Additionally, we will provide clinical information, and we may provide a short video of each patient and family to give contestants further phenotype information. This information will be provided by July 13, 2015, when the Challenge will officially launch. Families will not speak with contestants or media for the duration of the Challenge.

Teams will then have until September 21 to produce their reports. Winners and finalists will be chosen by an independent panel of judges and announced in November at Boston Children’s Global Pediatric Innovation Summit. $25,000 in prize money will be awarded. The $25,000 challenge was made possible by longtime hospital donor Rob Hale, CEO of Granite Telecommunications, his wife Karen and their family.

As with CLARITY 1, we will submit the proceedings of the Challenge for publication in a medical journal. Read more about CLARITY Undiagnosed.

Who should apply?

Any medical or research center is welcome to submit an application to participate in the CLARITY Undiagnosed Challenge. Up to 30 teams will be selected to participate.

Because the Challenge—and appropriate interpretation of genomic data—requires a multidisciplinary approach, teams that apply should ideally have members with experience in bioinformatics, genetics and medicine. We will provide all contestants with the opportunity to showcase their team and work. Read more.