Donald Ingber is interested in how cell structure and mechanics impact cellular biochemistry and tissue development.?? His research approach has combined techniques from various fields, including molecular cell biology, engineering, chemistry, physics, and computer science.

Ingber's angiogenesis research focuses on how the shape of a vascular blood vessel cell and the physical properties of its environment influence whether the cell grows, produces specialized products, moves, or dies. Through these efforts, Ingber has made pioneering contributions to the fields of angiogenesis, tissue engineering, mechanobiology, and systems biology. His work on how blood vessels form also led to the development of TNP-470, one of the first angiogenesis inhibitors to enter clinical trials.

Dr. Ingber simultaneously received his MD and PhD from Yale University. He was the Anna Fuller Research Fellow at Children's Hospital Boston and Harvard Medical School.

He is credited on over 20 patents which cover technologies ranging from new cancer drugs and drug-screening assays to medical devices, micromanufacturing techniques, and computer software.