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Department
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Stem Cell Program
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Hospital Title
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Director, Stem Cell Transplantation Program; Associate Director, Stem Cell Program
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Academic Title
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Samuel E Lux IV Professor of Hematology/Oncology
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Phone
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617-919-2013
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Fax
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617-730-0222
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Email
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George Daley
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Location
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300 Longwood Avenue
Karp-7
Boston MA 02115
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The laboratory focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, germ cell development, and mechanisms of oncogenesis.
Specific research programs are described briefly below:
Directed differentiation of HSCs from pluripotent stem cells: We study hematopoietic development in mouse embryos and differentiating cultures of human and mouse pluripotent stem cells to define the molecular genetic programs that enable formation of HSCs in experimental and therapeutic models. Our long-term goal is improved transplantation therapies for genetic and malignant blood disorders.
Derivation of genetically defined pluripotent stem cells: We use nuclear transfer, parthenogenesis, and reprogramming with defined genes to model combined cell and gene therapy of human genetic disorders.
Germ cell development and germ cell tumor biology: We have devised methods for directed differentiation of pluripotent stem cells into primordial germ cells in vitro, which provides an accessible in vitro model system for studying germ lineage commitment. We are studying genetic pathways that preserve pluripotency in the germ lineage and which become deranged in germ cell tumors.
Mechanisms of oncogenesis: We have a long-standing interest in molecular mechanisms of leukemia induction by the BCR/ABL oncoprotein in human Chronic Myeloid Leukemia, the classic malignancy of hematopoietic stem cells. Recent studies in our lab have focused on the role of the Lin28A/B genes that are linked to a variety of cancer types.
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Dr. Daley received a PhD in biology from MIT and an MD degree from Harvard Medical School through the Harvard-MIT Division of Health Sciences and Technology. He has been elected a fellow of the American Association for the Advancement of Science and a member of the American Society for Clinical Investigation, American Association of Physicians, and American Pediatric Societies. Dr. Daley was an inaugural winner of the NIH Director?s Pioneer Award, which provides a five year unrestricted grant to pursue highly innovative research, and received the Judson Daland Prize from the American Philosophical Society for achievement in patient-oriented research and the E. Mead Johnson Award from the American Pediatric Society for contributions to stem cell research.
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- Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly M, Daley GQ. Histocompatible parthenogenetic murine embryonic stem cells. Science 2007 315(5811):482-6. Epub 2006 Dec 14.
- Park I-H, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, and Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008 451(7175):141-6. Epub 2007 Dec 23.
- Park I-H, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell 2008 online August 7 PMID: 18691744.
- *Adamo L, *Naveiras O, McKinney-Freeman S, Mack PJ, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, #García-Cardeña G, #Daley GQ. Biomechanical forces promote embryonic hematopoiesis. Nature 2009 Jun 25;459(7250):1131-5.
- West J, Viswanathan SR, Yabuuchi A, Takeuchi A, Cunniff K, Park IH, Sero JE, Perez-Atayde A, Frazier AL, Surani MA, Daley GQ. A role for Lin28 in germ cell development and germ cell malignancy. Nature 2009 460(7257):909-13.
- Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ. Bone Marrow Adipocytes as Negative Regulators of the Hematopoietic Microenvironment. Nature 2009 Jul 9;460(7252):259-63.
- Agarwal S, Loh Y-H, McLoughlin EM, Huang J, Park I-H, Miller JD, Huo H, Rosana Okuka M, Maria dos Reis RM, Loewer S, Ng, H-H, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, and Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010 464(7286):292-6
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