|
|
 |
|
|
CHB Faculty Affiliate Members
|
|
|
More than 40 faculty members at Children's Hospital have joined the Stem Cell Program as Affiliate Members, reflecting the opportunities and vision that Stem Cell research offers across a wide range of disciplines and departments. Although not working directly within the CHB Stem Cell Program, many Affiliate Members are conducting research or exploring investigatory avenues closely related to its work.
The Affiliates participate in a range of events sponsored by the Stem Cell Program; through these events, members have an opportunity to exchange information, share discoveries, and build collaborations. The expertise, insights and research of the Affiliate Members add significantly to the resources of the Stem Cell Program at Children's Hospital.
|
|
|
If you are a member of the Children's Hospital Boston faculty and would like to join the Stem Cell Program as an Affiliate Member, please contact Christine Kent, Manager of the Stem Cell Program at Children's.
Affiliate members of the Stem Cell Program at Children's Hospital are also encouraged to join the Harvard Stem Cell Institute. The Institute was founded in 2004 to draw together Harvard's resources on stem cell research through the establishment of a cooperative community of scientists and practitioners, developing new ways to fund and support research, and promoting opportunities for open communication and education. Children's Hospital Boston, together with ten other Harvard-affilated teaching hospitals, the Harvard Medical School, the Faculty of Arts and Sciences,and many research institutions, is an active participant in the Institute. For information about how to become an individual member, go to www.stemcell.harvard.edu .
|
|
|
|
|
The range of research encompassed by the work of our affiliate members is extraordinary. Many of their past discoveries have changed the face of medical research. Their current explorations hold promise of even greater achievement, offering hope for progress toward eagerly awaited clinical therapies.
Brief introductions to the current focus of just a few of the Stem Cell Program's affiliate members are included below.
|
|
|
- JOYCE BISCHOFF
Joyce Bischoff's work has contributed to a greater understanding of the role of endothelial cells in angiogenesis. Endothelial cells line the interior of the heart and all of the blood vessels in the body. New endothelial cells are needed for growth of organs and tissue, and also to maintain a healthy vasculature. The source of these new endothelial cells was long thought to be from pre-existing blood vessels, but new studies clearly demonstrate that their progenitors - the cells that differentiate into endothelial cells - are present in the bone marrow and in the bloodstream. Her laboratory is looking at... More -->
- MICHAEL GREENBERG
Research in the Greenberg lab has focused on identifying the mechanisms by which extracellular stimuli trigger cellular responses that are critical for proliferation, differentiation, and survival of cells in the developing nervous system, and for the adaptive response of neurons in the mature nervous system. To this end,... More -->
- EMANUELLA GUSSONI
The Gussoni laboratory's long-term goal is to optimize a cell-based therapy for patients with muscular dystrophy. Dr. Gussoni and colleagues are now pursuing this goal by optimizing human muscle stem cell isolation and characterization, as well as by creating new animal models for pre-clinical testing. They are also comparing the transcriptome -- the set of active genes-- of human muscle stem cells to that of committed muscle cells using micro array technology. These studies are expected to lead to the identification of specific stem cell markers that will make it easier to purify stem cells from primary tissues. Down the road,... More -->
- ZHIGANG HE
Dr. He is interested in understanding the cellular and molecular mechanisms that determine the motility and directionality of developing and regenerating axons. He aims to use these paradigms to design therapeutic strategies to stimulate the outgrowth or retraction of specific axonal tracts in human diseases. To this end, He and colleagues are studying... More -->
- DONALD INGBER
Donald Ingber is interested in how cell structure and mechanics impact cellular biochemistry and tissue development. His research approach has combined techniques from various fields, including molecular cell biology, engineering, chemistry, physics and computer science. Ingber's angiogenesis research focuses on how the shape of a vascular blood vessel cell and the physical properties of its environment influence whether the cell grows, produces specialized products, moves, or dies. Through these efforts, Ingber has made pioneering contributions to... More -->
- LOUIS KUNKEL
Louis Kunkel has years of experience and scientific success in the understanding of the basis for muscular dystrophies. Over the past three decades, Dr. Kunkel has devoted his career to understanding the molecular basis of, and developing therapy for, neuromuscular disorders. Dr. Kunkel is universally recognized for the identification of the gene and encoded protein, dystrophin, which is altered in boys with Duchenne/Becker muscular dystrophy. Located at the inner face of the muscle cell membrane, dystrophin is an integral member of a multiprotein complex thought... More -->
- HONGBO LUO
The long-term goal of Dr. Luo's research is to elucidate the molecular mechanisms that control the number of neutrophils at the site of an inflammation. Neutrophil is the most abundant cell type among circulating white blood cells and constitutes the first line of defense against invading bacteria and other pathogens. The research focuses on signal pathways mediating neutrophil directional movement (chemotaxis) and moelcular mechanism of neutrophil spontaneous cell death. Currently, the laboratory is... More -->
- PAUL ROSENBERG
Paul Rosenberg's current research focuses on two areas; disorders of the brain and sleep disturbances. He seeks to understand the mechanisms of brain injury in order to provide a rational basis for preventing and treating important neurological disorders and diseases. In pursuit of this goal, he is working to characterize pathways of cell death in neurons and oligodendrocytes. He is currently investigating... More -->
- BRUCE YANKNER
Bruce Yankner's research focuses on neurodegenerative mechanisms in Alzheimer's disease and Down's syndrome. His laboratory has provided evidence that the beta amyloid protein causes neuronal cell death, which may contribute to the pathogenesis of dementia in Alzheimer's disease. He and his colleagues are currently focusing on the function of the presenilin genes, which cause familial Alzheimer's disease, and on environmental factors that may contribute to Alzheimer's disease. Recently, his team demonstrated... More -->
- BRUCE ZETTER
Bruce Zetter is a pioneer in understanding how cell movement affects tumor metastasis. In 1980, he made the key discovery that interferon alpha, which inhibits viral proliferation, also inhibits the locomotion of endothelial cells necessary for angiogenesis. His work led to the use of interferon alpha to treat hemangiomas. Dr. Zetter's laboratory's current focus is on tumor metastasis and on identifying diagnostic and prognostic markers that can guide treatment decisions, including a new prognostic marker for prostate cancer. Specifically, the investigators are... More -->
|
|
|
|
|
Frederick Alt: Charles A. Janeway Professor of Pediatrics
Nancy Andrews: Leland Fikes Professor of Pediatrics
Scott Armstrong: Assistant Professor of Pediatrics
Larry Benowitz: Associate Professor of Neurosurgery
Joyce Bischoff: Associate Professor of Surgery
David Breault: Instructor in Pediatrics
Gabriel Corfas: Associate Profesor of Neurology
Douglas Cotanche: Associate Professor of Otology and Laryngology
Allen Crocker: Associate Professor of Pediatrics
Judah Folkman: Julia Dyckman Andrus Professor of Pediatric Surgery
Markus Frank: Instructor in Medicine
Michael Freeman: Associate Professor of Surgery
Yuko Fujiwara: Instructor in Hematology
Anne Fulton: Associate Professor of Ophtamology
Raif Geha: James L. Gamble Professor of Pediatrics
Craig Gerard: Professor of Pediatrics
Norma Gerard: Professor of Medicine
Melvin Glimcher: Harriet M. Peabody Professor of Orthopedic Surgery
Richard Grand: Professor of Pediatrics
Michael Greenberg: Professor of Neurology
Emanuela Gussoni: Assistant Professor of Pediatrics
Peter Hauschka: Associate Professor of Oral and Developmental Biology
Xi He: Associate Professor of Neurology
Zhigang He: Assistant Professor of Neurology
Sui Huang: Assistant Professor, Vascular Biology
Donald Ingber: Judah Folkman Professor of Vascular Biology
Laurie Jackson-Grusby: Associate Professor of Neurology
Mark Keating: Professor of Cell Biology
Mark Kieran: Assistant Professor of Pediatrics
Stella Kourembanas: Associate Professor of Pediatrics
Jordan Kreidberg: Associate Professor of Pediatrics
Louis Kunkel: Professor of Pediatrics
Wayne Lencer: Associate Professor of Pediatrics
M.William Lensch: Instructor in Pediatrics
Olin Liang: Instructor in Pediatrics
Hongbo Luo: Assistant Professor of Pathology
Samuel Edward Lux IV: Robert A. Stranahan Professor of Pediatrics
S. Alex Mitsialis:Assistant Professor of Pediatrics
Robert Montgomery: Instructor in Pediatrics
Marsha Moses: Associate Professor of Surgery
Karen Moulton: Assistant Professor of Surgery
Stuart Orkin: David G. Nathan Professor of Pediatrics
Scott Pomeroy: Associate Professor of Neurology
Paul Rosenberg: Associate Professor of Neurology
Lynda Schneider: Associate Professor of Pediatrics
Leslie Silberstein: Professor of Pathology (Pediatrics)
Lois Smith: Associate Professor of Opthamology
Yang Teng: Assistant Professor of Surgery
Bruce Yankner: Professor of Neurology
Bruce Zetter: Charles Nowiszewski Professor of Cancer Biology
|
|
|
|
|
|
|
|
|
|
|
