Research Faculty

Mark Puder, MD, PhD

Department General Surgery
Hospital Title Associate in Surgery
Academic Title Associate Professor
Phone 617-355-1838
Fax 617-730-0298
Email Mark Puder
Location 300 Longwood Avenue
Boston
MA 02115

Research Overview

The goals of Mark Puder's research include:

  • the prevention and treatment of parenteral and enteral nutrition induced liver injury
  • understanding the role of angiogenesis and organ regeneration
  • the prevention of post-operative surgical adhesions

Dr. Puder's reseach team is currently conducting a clinical study on the prevention of parenteral nutrition liver injury based on their laboratory findings. They are also preparing a clinical study on the prevention of surgical adhesions.

About Mark Puder

  • 1986-1987 | Intern in Pediatrics, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT
  • 1987-1988 | Resident in Pediatrics, Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT
  • 1988-1989 | Intern in Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, MA
  • 1989-1991 | Resident in Surgery, New England Deaconess Hospital, Boston, MA
    1991-1992 Research Fellow, Department of Cellular and Molecular Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
  • 1992-1996 | Graduate Student, School of Arts and Sciences, Division of Medical Sciences, Harvard University, Cambridge, MA
  • 1993-1996 | Thesis Laboratory: Department of Medicine, Massachusetts General Hospital, Boston, MA
  • 1997-1998 | Resident in Surgery, Beth Israel-Deaconess Hospital, Boston, MA
  • 1998-1999 | Chief Resident in Surgery, Beth Israel-Deaconess Hospital Boston, MA
  • 1999-2000 | Associate Chief Resident in Pediatric Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA
  • 2000-2001 | Chief Resident in Pediatric Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA

Key Publications 

  • Lee SI, Valim C, Johnston P, Le HD, Meisel J, Arsenault DA, Gura KM, Puder M. The Impact of Fish Oil-Based Lipid Emulsion on Serum Triglyceride, Bilirubin, and Albumin Levels in Children with Parenteral Nutrition-Associated Liver Disease. Pediatr Res. 2009 Aug 14. [Epub ahead of print] PMID: 19687773
     
  • Puder M, Valim C, Meisel JA, Le HD, de Meijer VE, Robinson EM, Zhou J, Duggan C, Gura KM. Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg. 2009 Sep; 250(3): 395-402. PMID: 19661785
     
  • de Meijer VE, Gura KM, Le HD, Meisel JA, Puder M. Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience. JPEN J Parenter Enteral Nutr. 2009 Sep-Oct; 33(5): 541-7. Epub 2009 Jul 1. Review. PMID: 19571170
     
  • Le HD, Meisel JA, de Meijer VE, Gura KM, Puder M. The essentiality of arachidonic acid and docosahexaenoic acid. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep; 81(2-3): 165-70. Epub 2009 Jun 18. PMID: 19540099
     
  • Puder M. Infant Parenteral Nutrition-Associated Cholestasis: A Severe Iatrogenic Disease. JPEN J Parenter Enteral Nutr. 2009 Apr 30. [Epub ahead of print] PMID: 19407103
     
  • Goessling W, North TE, Schmitt S, Lord AM, Lee S, Stoick-Cooper CL, Weidinger G, Puder M, Daley GQ, Moon RT, Zon LI. Genetic interaction between PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 Mar 20; 136(6): 1136-47. PMID: 19303855.
     
  • De Meijer VE, Gura KM, Le HD, Meisel, JA, Puder M. Fish Oil-Based Lipid Emulsions Prevent and Reverse Parenteral Nutrition-Associated Liver Disease: The Boston Experience. Journal of Parenteral and Enteral Nutrition 2008 (in press).
     
  • Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008 May 20. [Epub ahead of print] PMID: 18585699.
     
  • Henkes LE, Sullivan BT, Lynch MP, Kolesnick R, Arsenault D, Puder M, Davis JS, Rueda BR. Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo. PNAS. 2008 Jun 3; 105(22): 7670-5. Epub 2008 May 27. PMID: 18505843.
     
  • Strijbosch RAM, Lee S, Arsenault DA, Andersson C, Gura KM, Bistrian BR, Puder M. Fish Oil Prevents Essential Fatty Acid Deficiency and Enhances Growth: Clinical and Biochemical Implications. Metabolism. 2008 May; 5(5): 698-707; PMID: 18442636.
     
  • Gura KM, Lee S, Valim C, Zhou J, Kim S, Modi BP, Arsenault DA, Strijbosch RA, Lopes S, Duggan C, Puder M. Safety and Efficacy of a Fish Oil-based Fat Emulsion in the Treatment of Parenteral Nutrition-associated Liver Disease. Pediatrics. 2008; 121: e678-e686; PMID: 18310188.
     
  • Beaudry P, Hida Y, Udagawa T, Alwayn IP, Greene AK, Arsenault D, Folkman J, Heymach JV, Ryeom S, Puder M. Endothelial progenitor cells contribute to accelerated liver regeneration. J Pediatr Surg. 2007 Jul; 42(7):1190-8; PMID: 17618879.
     
  • Lee S, Gura KM, Puder M. Omega-3 fatty acids and liver disease. Hepatology. 2007; 45(4): 841-845; PMID: 1739527.
     
  • Gura KM, Lee S, Valim C, Zhou J, Kim S, Modi BP, Arsenault DA, Strijbosch RA, Lopes S, Duggan C, Puder M. Safety and Efficacy of a Fish Oil-based Fat Emulsion in the Treatment of Parenteral Nutrition-associated Liver Disease Pediatrics. 2007 (in press)
     
  • Sakurai MK, Lee S, Arsenault DA, Nose V, Wilson JM, Heymach JV, Puder M. Vascular endothelial growth factor accelerates compensatory lung growth after unilateral pneumonectomy. Am J Physiol Lung Cell Mol Physiol. 2007; 292 (3): L742-7.
     
  • Alwayn IP, Andersson C, Lee S, Arsenault DA, Bistrian BR, Gura KM, Nose V, Zauscher B, Moses M, Puder M. Inhibition of matrix metalloproteinases increases PPAR-{alpha} and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am J Physiol Gastrointest Liver Physiol. 2006; 291(6): G1011-9.
     
  • Alwayn IP, Gura K, Nosé V, Zausche B, Javid P, Garza J, Verbesey J, Voss S, Ollero M, Andersson C, Bistrian B, Folkman J, Puder M. Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease. Pediatr Res. 2005;57(3):445-52.
     
  • All of Dr. Puder's publications on PubMed

Curriculum Vitae