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Department
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General Surgery
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Hospital Title
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Staff Surgeon
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Academic Title
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Assistant Professor in Surgery
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Phone
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617-355-7800
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Fax
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617-730-0477
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Email
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Terry L. Buchmiller
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Location
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300 Longwood Avenue
Fegan 3
Boston
MA 02115
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Terry Buchmiller's investigations utilize a fetal rabbit IUGR model for in-utero studies of GI development. Her team performs surgical implantation of amniotic fluid catheters for supplementation studies and have developed open fetal surgery techniques to study congenital malformations. Experimental amniotic fluid supplementation has successfully reversed IUGR in this model. Small intestinal nutrient absorption in the IUGR fetus has been improved with intra-amniotic hormonal administration, including EGF and gastrin. Current studies are seeking to elucidate the molecular events controlling these processes. We are also assessing in-vivo fetal foregut motility in this rabbit model of IUGR.
Major research goals:
1. Understand the mechanisms underlying the development of fetal small bowel nutrient transport and motility.
2. Define the role of EGF in fetal gut development.
3. Design potential in-utero treatments for intrauterine growth retardation utilizing amniotic fluid supplementation.
Dr. Buchmiler seeks to design and test potential in-utero treatment for IUGR fetuses by the use of amniotic fluid supplementation.
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MD, University of California, Davis
1988-1989 Intern in Surgery, UCLA Medical Center, Los Angeles, CA
1989-1995 Resident in Surgery, UCLA Medical Center, Los Angeles, CA
1990-1992 Research Fellow, Division of Pediatric Surgery, UCLA Medical Center, Los Angeles, CA
1995-1996 Associate Chief Resident in Pediatric Surgery, Children's
Hospital, Harvard Medical School, Boston, MA
1996-1997 Chief Resident in Pediatric Surgery, Children's Hospital, Harvard Medical School, Boston, MA
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- Buchmiller TL, Kim CS, Chopourian HL, Fonkalsrud EW. Transamniotic fetal feeding: enhancement of growth in a rabbit model of intrauterine growth retardation. Surgery 116: 36-41, 1994.
- Sase M, Lee JJ, Park JY, Thakur A, Ross MJ, Buchmiller-Crair TL. Ontogeny of fetal rabbit upper gastrointestinal motility. J Surg Res 101: 68-72, 2001.
- Cellini C, Xu J, Arriaga A, Buchmiller-Crair TL. Effect of epidermal growth factor (EGF) infusion on fetal rabbit intrauterine growth retardation (IUGR) and small intestinal development. J Pediatr Surg 39: 891-897, 2004.
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