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CHILDHOOD AND ADOLESCENT OSTEOPOROSIS- This study evaluates the drug, Alendronate, to determine if it will prevent or reverse the severe bone loss known as osteoporosis that develops in children receiving chronic steroid therapy for debilitating diseases involving their joints or bowels.
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METFORMIN IN OVERWEIGHT CHILDREN- a randomized clinical trial to assess the effectiveness of lifestyle changes with or without the medication Metformin, a drug used to treat obesity in adults, is safe and effective in treating adolescent obesity.
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IMPACT OF BODY COMPOSITION ON DRUG TREATMENTS IN PEDIATRIC PATIENTS WITH CANCER- The purpose of the study is to learn about the pharmacology of doxorubicin, an anticancer drug used in thousands of children each year. Too much doxorubicin can be toxic and life threatening, and too little may have insufficient anti cancer activity.
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PEDIATRIC ITP- Idiopathic Thrombocytopenic purpura (ITP) is a bleeding disorder that can be difficult to treat in some children. This study is designed to determine the safety and efficacy of an innovative treatment for this serious disorder
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NEONATAL SURGICAL DATABASE- Major congenital malformations can cause serious disability and death in newborn infants. Urgent surgical care is often required soon after birth. Because many of these conditions are uncommon, pediatric surgeons may not know the best way to manage these babies. The Network is developing a database that will enable surgeons to assess and share techniques with the aim of understanding the optimal way to handle these vulnerable infants.
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PALLIATIVE CARE FOR DYING CHILDREN- it is estimated that there are approximately 400,000 chronically ill children in the United States. This study is designed to assess the quality of life of children with life limiting illnesses and to develop interventions that can improve the manner in which children and their families are comforted at life's end.
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DIAPHRAGMATIC HERNIAS IN INFANTS- Congenital Diaphragmatic Hernia (CHD) is a birth defect that occurs when the diaphragm does not fully form, allowing organs to enter the chest cavity and interfere with normal lung growth. This study will test an innovative treatment intended to induce lung growth and help reduce the number of death attributed to this life-threatening defect.
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Gordon, Catherine, MD, MSc
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Childhood and Adolescent Osteoporosis
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Lenders, Carine, MD, MS
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Metformin in Overweight Children
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Neufeld, Ellis, MD PhD
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Pediatric ITP
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Grier, Holcombe, MD
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Impact of Body Composition on Drug Treatments in Pediatric Patients with Cancer
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Jaksic, Tom, MD, PhD
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Neonatal Surgical Database
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