Adrianne Kolpak, Ph.D., Post-doctoral Research Fellow
Adrianne earned her Ph.D. in cell biology from the University of Massachusetts Medical School in 2010. Her thesis research focused on the concentration-dependent effect of Sonic hedgehog on axon guidance and membrane trafficking within axonal growth cones. Adrianne joined the Engle lab as a postdoctoral fellow in August 2010. She is currently investigating the effect of pathological mutations in beta-III tubulin on axon growth and guidance in order to better understand the etiology of the eye movement disorder, CFEOM3.
Representative publications from graduate school:
- Peter, C.J., Evans, M., Thayanithy, V., Taniguchi-Ishigaki, N., Bach, I., Kolpak, A., Bassell, G., Rossoll, W., Lorson, C.L., Bao, Z.Z., Androphy, E.J. 2011. The COPI vesicle complex binds and moves with Survival Motor Neuron within axons. Hum Mol Genet 20, 1701-11.
- Jiang, J., Kolpak, A.L., and Bao, Z.Z. 2009. Distinct roles of myosin IIA and IIB isoforms in macropinosome formation in Neuro-2a cells. Cell Motil Cytoskeleton, 1-12.
- Kolpak, A.L., Jiang, J., Guo, D., Standley, C., Bellve, K., Fogarty, K., and Bao, Z.Z. 2009. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. J. Neurosci 29, 10488-98.
- Kolpak, A., Zhang, J., and Bao, Z.Z. 2005. Sonic hedgehog has a dual effect on the growth of retinal axons depending on its concentration. J. Neurosci 25, 3432-3441.
Contact information: Adrianne.Kolpak@childrens.harvard.edu