Chen Wu, Ph.D., Post-doctoral Research Fellow
Chen obtained her B.S. from the University of Science and Technology of China, in Heifei, majoring in Biology. In 2002, she entered the Ph.D. program in developmental neurobiology at the City of Hope Graduate School of Biological Sciences in California. In her graduate work, she used mouse models to characterize a signaling pathway essential for maintenance of neural progenitor cells. Following graduation in the summer of 2008, Chen joined the Engle lab to work on the neuroanatomic description of the Tubb3R262C mouse, a model of the human axon guidance disorder, CFEOM3. Chen's current research addresses the hypothesis that Tubb3, unlike other beta-tubulins, plays a unique role in axonal guidance.
Publications from prior lab
- Qiu R, Wang X, Davy A, Wu C, Murai K, Zhang H, Flanagan JG, Soriano P, Lu Q. Regulation of neural progenitor cell state by ephrin-B. J Cell Biol. 2008;181(6):973-83.
- Wu C, Qiu R, Wang J, Zhang H, Murai K, Lu Q. ZHX2 interacts with ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. J Neurosci. 2009;29(23):7404-12.
Publication from Engle lab
- Tischfield MA, Baris HN*, Wu C*, Rudolph G, Van Maldergem L, He W, Chan W-M, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcategui CE, De Uzcategui N, Collins ML, Sener EC, Wabbels B, Hellebrand H, Meitinger T, de Berandinis T, Magli A, Schiavi, C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes, M., Flaherty MP, Jamieson R V, Moller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML Jr, Pellman D, Engle EC. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010; 140:74-87. * these authors contributed equally