Max Tischfield joined the Engle lab in March of 2004 as a graduate student in the department of neuroscience at Harvard Medical School. Max had earned his B.A. in Cell Biology and Neuroscience from Rutgers University, where he was a Henry Rutgers Scholar doing 3 years of honors research on the development of the dorsal CNS and cerebellum under the guidance of Dr. James Millonig. This research led to a senior thesis entitled "A transcription factor code for dorsal CNS development." As a graduate student in the Engle lab, Max investigated the genotype/phenotype correlations of HOXA1 mutations and then did a broad-based, thorough study of TUBB3 mutations that cause a spectrum of CFEOM 3 disorders of axon guidance and maintenance. He became a post-doctoral research fellow in the lab of Dr. Jeremy Nathans at Johns Hopkins University School of Medicine in January 2010, in order to further study neuronal development.
Publications-Original reports
1. Tischfield MA, Bosley TM, Salih MA, Alorainy IA, Sener EC, Nester MJ, Oystreck DT, Chan WM, Andrews C, Erickson RP, Engle EC. Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. Nat Genet. 2005; 37(10):1035-1037.
2. Tischfield MA, Chan W-M, Grunert J-F, Andrews C, Engle EC. HOXA1 mutations are not a common cause of Duane Anomaly. American Journal of Medical Genetics A. 2006 140(8):900-902. PMCID: PMC2553396
3. Bosley TM, Salih MA, Alorainy IA, Oystreck DT, Nester M, Abu-Amero KK, Tischfield M, Engle EC. Clinical characterization of the HOXA1 syndrome BSAS variant. Neurology, 2007;69(12):1245-53.
4. Bosley TM, Alorainy IA, Salih MA, Aldhalaan HM, Abu-Amero KK, Oystreck DT, Tischfield MA, Engle EC, Erickson RP. The clinical spectrum of homozygous HOXA1 mutations. American Journal of Medical Genetics A 2008; 146(10):1235-40.
5. Tischfield MA, Baris HN, Wu C, Rudolph G, Van Maldergem L, He W, Chan W-M, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcategui CE, De Uzcategui N, Collins ML, Sener EC, Wabbels, B, Hellebrand H, Meitinger T, de Berandinis T, Magli A, Schiavi, C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes M, Flaherty MP, Jamieson RV, Moller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML Jr, Pellman D, Engle EC. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010; 140: 74-87. PMCID: PMC Journal ? In process
Chapters, reviews
1. Tischfield MA, Engle EC. HOXA1 and the Bosley-Salih-Alorhainy and Athabascan Brainstem Dysgenesis Syndromes. Book Chapter to appear in "Inborns Errors of Development, 2nd edition", C J Epstein, R P Erickson, A Wynshaw-Boris, Eds., Oxford University Press, 2008.
Awards
American Society of Human Genetics, Predoctoral Presentation Award Finalist, 55th Annual Meeting, Salt Lake City, UT, October 2005.
Fellowships
Albert J. Ryan Fellow Illick Fellow
Contact Information:
Dr. Max Tischfield
Department of Molecular Biology and Genetics
Johns Hopkins University School of Medicine
725 North Wolfe St.
Baltimore, MD 21205
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