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Elizabeth C. Engle, M.D., Principal Investigator
     
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Elizabeth sharing the E. Mead Johnson award with her daughter, Saoirse, May 16th 2005

Elizabeth Engle is a pediatric neurologist and genetics researcher at Children's Hospital and an Associate Professor of Neurology at Harvard Medical School. She can be contacted via the Engle laboratory website, or directly at Elizabeth Engle engle@enders.tch.harvard.edu.

Bibliography: Please click on Publications for a listing of Dr. Engle's publications, as well as using a direct link to PubMed for the most recent peer-reviewed publications that may not yet be on the website.

CURRICULUM VITAE

PART I: GENERAL INFORMATION

Education
1980 B.A. Middlebury College, Middlebury, VT summa cum laude
1985 M.D. The Johns Hopkins University School of Medicine, Baltimore, MD

Postdoctoral Training

Internships and Residencies:
1985-1988 Intern & Resident, Pediatrics, The Johns Hopkins Hospital, Baltimore, MD
1988-1989 Resident, Neuropathology, Massachusetts General Hospital, Boston, MA
1989-1992 Resident, Harvard Longwood Neurology Training Program, Boston, MA
1989-1992 Resident, Pediatric Neurology, Children's Hospital Boston, Boston, MA

Clinical Fellowships:
1992-1994 Clinical Fellow in Neurology, Children's Hospital Boston, Boston, MA

Research Fellowships:
1992-1996 Research Fellow in Genetics, Children's Hospital Boston, Boston, MA with Louis M. Kunkel, Ph.D. and Alan H. Beggs, Ph.D.

Licensure and Certification
1985-1986 State of Ohio License Registration
1989 American Board of Pediatrics
1992 Massachusetts License Registration
1993 American Board of Psychiatry and Neurology (Special competence in Child Neurology)
1996&2002 American Board of Pediatrics, Recertification

Academic Appointments
1988-1989 Clinical Fellow in Pathology, Harvard Medical School
1989-1992 Clinical Fellow in Neurology, Harvard Medical School
1992-1996 Instructor in Neurology, Harvard Medical School
1997-2002 Assistant Professor in Neurology, Harvard Medical School
2001-Pres. Faculty Affiliate, Program in Neuroscience, Harvard Medical School
2002-Pres. Associate Professor in Neurology, Harvard Medical School

Hospital Appointments
1980-1981 Research Technician, Ohio State University School of Medicine, Columbus, Ohio
1992-1993 Clinical Fellow in Neurology, Children's Hospital Boston
1994-2002 Assistant in Neurology, Children's Hospital Boston
1992-1996 Research Fellow in Genetics, Children's Hospital Boston
1999-Pres. Research Associate in Medicine (Genetics), Children's Hospital Boston
2002-Pres. Senior Associate in Neurology, Children's Hospital Boston
2003-Pres. Member, Program in Genomics, Children's Hospital Boston

Awards and Honors
1979 National Science Foundation Undergraduate Research Participation Grant, Department of Biology, University of Rochester
1979 Phi Beta Kappa Society member, Junior Year, Middlebury College Chapter
1980 Summa Cum Laude, Middlebury College, Middlebury, VT
1980 Highest Honors in Biology, Middlebury College, Middlebury, VT
1983-1985 Joseph Collins Scholarship, Johns Hopkins School of Medicine
1985 Alpha Omega Alpha member, Johns Hopkins School of Medicine Chapter
1991 von Meyer Travel Award, Children's Hospital, Boston, MA
1992 Farley Fund Fellowship, Children's Hospital, Boston, MA
1994 von Meyer Travel Award, Children's Hospital, Boston, MA

1997 Children's Hospital Research Scholar Award, Boston, MA
2004 Robb-Petersen Lecturer, Dept of Ophthalmology, Children's Hospital Boston
2005 Recipient of the 2005 E. Mead Johnson Award for Research in Pediatrics from the Society for Pediatric Research, Washington DC.

PART II: RESEARCH, TEACHING, AND CLINICAL CONTRIBUTIONS
Funding Information

Research Applications:
Active (research):

1999-2010 NIH/NEI R01 EY12498, PI, Molecular basis of congenital strabismus.
2005-2008 NIH/NEI R01 EY14298-S, PI, The Phenotype and genotype correlations of strabismus.
2001-2006 NIH/NEI R01 EY13583, PI, Genetic and anatomic basis of the fibrosis syndromes.
2004-2005 NIH/NEI R01 EY13583-04S1, PI, Genetic and anatomic basis of the fibrosis syndromes.
2001-2006 NIH/NINDS P01 NS40828, PI of Core Project, Gene expressing in normal and diseased muscle during development.
2004-2009 NIH/NEI R01 EY015298, PI, Genetic Etiologies of Horizontal Strabismus.

Other (research):
1999- Faculty member, The Childrens Hospital Boston Mental Retardation Research Center 5P30HD018655-23.
2000- Faculty member, Training Grant in Genetics, HMS, Cynthia Morton PI. T32 GM07748.
2005- Faculty member, Molecular Basis of Eye Diseases, NEI Postdoctoral Training Grant T32EY07145.

Postdoctoral funding to members of Engle lab:
2002-2003 Maria Pia Rogines Velo supported by a Knights Templar Eye Foundation, Inc.
2004-2006 Hagit Baris supported by a Kirschstein-NRSA Individual Fellowship Grant.

Past (research):
1992-1994 NIH Training Grant, Neurology, recipient, Children's Hospital, Boston.
1994-1999 NIH/NEI, K11 EY00336, PI, Cloning of a congenital extraocular muscle fibrosis gene.
1996-1997 Fight for Sight, PI, Linkage refinement and physical mapping of a gene for congenital ptosis.
1997-1998 Fight for Sight, PI, Cloning a gene for isolated congenital ptosis.
1997-1999 Charles H. Hood Foundation Research Grant, PI, Cloning the gene for congenital fibrosis of the extraocular muscles.
1997-1998 William F. Milton Fund, PI, Cloning the gene for congenital fibrosis of the extraocular muscles.
1997-1998 William Randolph Hearst Fund, PI, Cloning the gene for congenital fibrosis of the extraocular muscles.
1998-2000 Childrens Hospital Research Scholar Award Grant, PI, Genetics of congenital oculomotility disorders and oculomotor nerve development.
2000-2001 Fight for Sight, PI, Genetic mapping of a gene for Duane syndrome with radial ray anomalies (Okihiro syndrome).
2001-2002 Fight for Sight, PI, Identification of the DURS3 gene mutated in Duane syndrome with radial ray anomalies (Okihiro syndrome).

Contact Information:
Elizabeth C. Engle, M.D.
Principal Investigator
Division of Genetics, Enders 5
Children's Hospital
300 Longwood Avenue
Boston, MA 02115
Tel: 617-919-4030
Fax: 617-730-0253
Email: Elizabeth Engle

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