Paul H. Lerou, MD
|Hospital Title||Assistant in Medicine|
|Academic Title||Assistant Professor of Pediatrics, HMS|
|Paul H. Lerou|
Brigham and Women's Hospital
Department of Newborn Medicine, Harvard Institutes of Medicine
Our research goals are to advance the fundamental understanding of pluripotent stem cell biology and to explore how failure of genomic integrity impacts human development. We are developing novel live-cell and fixed-cell imaging techniques to study mitotic progression and genomic stability in human pluripotent stem cells. These techniques will be coupled with single cell analysis and computational biology approaches to improve our understanding of how cell cycle regulation and pluripotency are coupled.
About Paul H. Lerou
Dr. Lerou obtained his medical degree at Jefferson Medical College. He trained in pediatrics at Children’s Hospital Boston, and in neonatology in the Harvard Neonatal-Perinatal Fellowship Training Program. His post-doctoral research on embryonic stem cell derivation was done in the George Daley Laboratory, HHMI, Children’s Hospital Boston. He is an attending neonatologist in the Brigham & Women’s Neonatal Intensive Care Unit.
- Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ. Human embryonic stem cell derivation from poor-quality embryos. Nat Biotechnol. 2008 Feb; 26(2):212-4.
- Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Cell cycle adaptations of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 108, 19252-19257 (2011).
- Guan X, Yabuuchi A, Huo H, Ginsberg E, Racowsky C, Daley GQ, Lerou PH. Derivation of human embryonic stem cells with NEMO deficiency. Stem Cell Research. 2012 Jan.