• A prospective longitudinal study observing a cohort of children with advanced cancer and their families. It is designed to delineate the quality of key elements of care by studying parent and physician perceptions about prognosis and treatment goals, symptoms, and quality of life in children.


• An intervention that provides feedback on symptom and quality-of-life scores as a component of the routine care of children with advanced cancer. This feedback is provided by a computerized data collection system called Pediatric Quality of Life Evaluation of Symptoms Technology (PediQUEST). The system generates electronic mail notifications alerting providers to repeated high levels of symptom distress. This, in turn, may lead to better control of symptoms and result in less distress. Greater attention to quality of life also may stimulate parent and physician communication about prognosis and treatment goals and lead to earlier decision-making about palliative care outcomes.


• A collaboration with Dr. Charles Berde from the Pain Treatment Service at Children's Hospital Boston on a multicenter trial assessing the role of methylphenidate in the treatment of fatigue and somnolence in children with advanced cancer.

Dr. Wolfe received her MD from Harvard Medical School and her MPH from Harvard School of Public Health. She completed an internship, residency and chief residency in pediatrics at Children's Hospital Boston and a fellowship at Children's Hospital Boston and Dana-Farber Cancer Institute.

She received a Citation of Honor, Circle of Life Award in 2001.