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Department
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Hematology/Oncology
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Hospital Title
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Associate in Medicine
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Academic Title
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Associate Professor of Pathology
and Pediatrics
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Phone
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617-732-5152
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Fax
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617-278-6913
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Email
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Jonathan Fletcher
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Location
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Dana-Farber Cancer Institute
75 Francis Street
Boston MA 02115
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Jonathan Fletcher's research is directed at elucidating molecules within cancer cells that are potential targets for therapeutic intervention. In recent collaborations he has identified:
- A defective form of the enzyme platelet-derived growth factor recepter alpha (PDGFRA), that is associated with many gastrointestinal stromal tumors (GIST).
- A fusion of the proteins BRD4-NUT.
- An Alpha-TFEB fusion in renal tumors.
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Jonathan Fletcher received his MD from Boston University. He completed an internship, residency, and chief residency at University Hospital, Boston and fellowships at Dana-Farber Cancer Institute and Children's Hospital Boston and at Brigham and Women's Hospital.
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- French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde A, Fletcher JA. BRD4-NUT fusion oncogene: A novel mechanism in aggressive carcinoma. Cancer Research 2003; 63: 304-307.
- Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proceedings of the National Academy of Sciences USA 2003; 100: 6051-6056.
- Heinrich MC, Corless C, Duensing A, McGreevey L, Chen C-J, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CDM, Fletcher JA. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003; 299: 708-710.
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