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Department
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Hematology/Oncology
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Hospital Title
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President Emeritus,
Dana-Farber Cancer Institute
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Academic Title
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Robert A. Stranahan
Distinguished Professor of Pediatrics
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Phone
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617-632-5389
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Fax
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617-632-2161
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Email
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David Nathan
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Location
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Dana-Farber Cancer Institute
44 Binney Street
Boston MA 02115
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The Nathan laboratory is exploring the genetic basis of Fanconi anemia and Diamond-Blackfan anemia and attempting to correct these disorders either by gene transfer or haploidentical bone marrow transplantation.
In addition, Dr. Nathan conducts clinical research in new oral iron chelating agents. He is actively investigating a new oral iron chelator, ICL670, which promises to be very effective in the transfusion management of thalassemia and other marrow disorders requiring chronic transfusion. He also chairs the Steering Committee of the Thalassemia Clinical Research Network of the National Heart, Lung, and Blood Institute (a part of the National Institutes of Health) which is pursuing several different clinical trials in the management of thalassemia.
Much of Dr. Nathan's effort is also devoted to providing a better understanding of NIH and national policy in the area of clinical research, and he has authored several papers on this subject in recent years.
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David Nathan received an MD from Harvard Medical School. He completed an internship and residency at Brigham and Women's Hospital and a fellowship at the National Cancer Institute.
He is the recipient of numerous awards, including the National Medal of Science, 1990; the American Philosophical Society, 1999; the Annual Award for Excellence in Clinical Research, NIH, 1996; the Henry Stratton Medal, American Society of Hematology, 1995; and the Thomas Hart Benton Medallion, Indiana University, 1997.
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- Nathan DG. Search for improved therapy of sickle cell anemia. Journal of Pediatric Hematology and Oncology 2002; 24: 700-703.
- Shimamura A, Montes de Oca R, Svenson JL, Haining N, Moreau LA, Nathan DG, D'Andrea AD. A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood 2002; 100: 4649-4654.
- Gazda H, Lipton JM, Willig TN, Ball S, Niemeyer CM, Tchernia G, Mohandas N, Daly MJ, Ploszynska A, Orfali KA, Vlachos A, Glader BE, Rokicka-Milewska R, Ohara A, Baker D, Pospisilova D, Webber A, Viskochil DH, Nathan DG, Beggs AH, Sieff CA. Evidence for linkage of familial Diamond-Blackfan anemia to chromosome 8p23.3-p22 and for non-19q non-8p disease. Blood 2001; 97: 2145-2150.
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