The Children's Oncology Group a consortium of cancer treatment centers across the United States, Canada, and other countries, works on the design and implementation of studies regarding Ewings' sarcoma, osteosarcoma, rhabdomyosarcoma, and other soft tissue sarcomas. Dr. Grier is an active member of the Bone Tumor Disease Committee and the Soft Tissue Sarcoma Committee of this group.

As part of the Pediatric Solid Tumor group at DFCI and Children's Hospital, Dr. Grier and colleagues help organize laboratory and clinical cross talk.

Dr. Grier is also involved in cancer survivor studies that focus on the late effects of chemotherapy, which are led by Dr. Lisa Diller at the David B. Perini Jr. Quality of Life Clinic at DFCI. In addition, he participates in a study of the best application of palliative care through work with the Pediatric Advanced Care Team, led by Dr. Joanne Wolfe.

Holcombe Grier received his MD from the University of Pennsylvania. He trained in pediatrics, internal medicine, and infectious disease at the University of North Carolina.

He is currently on the executive committee of the Children's Oncology Group, and is a trustee for the American Society of Pediatric Hematology/Oncology. Dr. Grier was named Ray A. Kroc Visiting Professor of Pediatrics at The Hospital for Sick Children and McMaster University, Toronto and Hamilton, Canada in 1999. He received the Charles A. Janeway Award for Excellence in Clinical Teaching of Children's Hospital House Staff in 1992.