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Department
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Cardiology
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Hospital Title
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Associate in Cardiology
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Academic Title
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Assistant Professor of Pediatrics
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Phone
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617-355-2731
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Fax
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617-739-3784
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Email
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Roger Breitbart
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Location
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300 Longwood Avenue
Farley-2
Boston MA 02115
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Roger Brietbart's laboratory research interests have focused on mechanisms of cardiac gene regulation, and on the application of genomic strategies for identification of novel molecular pathways in the cardiovascular system. From 1996-2002 he headed the cardiovascular drug target discovery programs at Millennium Pharmaceuticals, Inc., in Cambridge, MA. Current research focuses on strategies to identify novel disease genes in congenital heart disease, particularly tetralogy of Fallot, and to elucidate genotype-phenotype correlations.
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Roger Breitbart received his MD from Harvard Medical School. He completed an internship, residency, and fellowship at Children's Hospital Boston.
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- Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. Journal of Molecular and Cellular Cardiology 20003 35: 1043-1053.
- Herman MP, Sukhova GK, Libby P, Gerdes N, Tang N, Horton DB, Kilbride M, Breitbart RE, Chun M, Schoenbeck U. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation 2001;104:1899-1904.
- Acton S, Jeyaseelan R, Kadambi VJ, Breitbart RE. Array transcription profiling: molecular phenotyping of rodent cardiovascular models. In: Hoit BD, Walsh RA, eds. Cardiovascular Physiology in the Genetically Engineered Mouse, 2nd Ed. Boston: Kluwer, 2002:53-61.
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