The Woolf Laboratory
Christian von Hehn, MD, PhD
Having graduated from medical school in 2003 at Kiel University, Germany, I worked with Dr. Leonard Kaczmarek. In 2004, I went on to the neuroscience graduate program at Yale University, and received my PhD in 2009 studying nociceptive TRP channels with Dr. Sven Jordt.
I am interested in the interaction between the peripheral nervous system and the immune system during acute and chronic inflammation. Using electrophysiological and imaging methods, my aim is to elucidate signaling molecules and cell types involved in sensory neuronal sensitization and immune cell activation.
Bessac B.F., Sivula M.*, von Hehn C.A.*, Caceres A.I., Escalera J., Jordt S.E. Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14.
Brown M.R , Kronengold J , Gazula V.R., Spilianakis C.G., Flavell R.A., von Hehn C.A., Bhattacharjee A., Kaczmarek L.K. Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation. J Physiol. 2008 Nov 1;586(Pt 21):5161-79.
Escalera J.*, von Hehn C.A.*, Bessac B.F., Sivula M., Jordt S.E. TRPA1 Mediates the Noxious Effects of Natural Sesquiterpene Deterrents. J Biol Chem. 2008 Aug 29;283(35):24136-44.
Bessac B.F., Sivula M., von Hehn C.A., Escalera J., Cohn L., Jordt S.E. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 2008 May;118(5):1899-910.
Chen H., von Hehn C.A., Kaczmarek L.K., Ment L.R., Pober B.R., Hisama F.M. Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia. Neurogenetics. 2007;8(2):131-5.
Kaczmarek L.K., Bhattacharjee A., Desai R., Gan L., Song P., von Hehn C.A., Whim M.D., Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hear Res. 2005; 206(1-2):133-45.
Bhattacharjee A., von Hehn C.A., Mei X., Kaczmarek L.K. Localization of KNa1.2 (Slick), a novel Sodium-dependent Potassium Channel, in the Rat Central Nervous System. J. Comp. Neurol. 2005; 484(1):80-92.
von Hehn C.A.*, Bhattacharjee A.*, Kaczmarek L.K. Loss of Kv3.1 tonotopicity and alterations in CREB signaling in central auditory neurons of hearing impaired mice. J. Neurosci. 2004; 24(8):1936-40.
Macica C.M., von Hehn C.A., Wang L.Y., Ho C.H., Yokoyama S., Joho R.H., Kaczmarek L.K. Modulation of the Kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. J Neurosci. 2003; 23(4):1133-41.