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Department
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Division of Hematology/Oncology
Department of Medicine
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Hospital Title
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Director, Center for Platelet Research Studies
Director, Thrombosis Program and Anticoagulation Service
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Academic Title
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Phone
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617-919-2116
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Email
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alan.michelson@childrens.harvard.edu
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Location
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300 Longwood Avenue
Karp 08213
Boston MA 02115
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Dr. Michelson's research group, the Center for Platelet Research Studies (CPRS), is an internationally recognized, multidisciplinary center for the study of platelets by state-of-the-art methods. The CPRS is an integrated research group that performs basic bench research, translational research, and clinical research on platelets and related aspects of hemostasis and thrombosis.
A particular focus of research in the CPRS is antiplatelet therapy, including characterization of:
- Novel molecules and mechanisms for therapeutic platelet inhibition
- The effects of antiplatelet agents on coagulation and inflammation
- The relationship between the degree of inhibition of platelet function and clinical outcomes (thrombosis vs. hemorrhage)
- The use of in vitro platelet function tests to guide antiplatelet therapy in order to obtain better clinical outcomes
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Dr. Michelson received his medical degree with honors from the University of Adelaide, Australia and was a Fulbright Scholar at Harvard Medical School. Dr. Michelson is the editor of the textbook "Platelets" (Elsevier/Academic Press). The first edition of "Platelets", published in 2002, was the winner of the Best Book in Medical Science Award from the Association of American Publishers; the 71-chapter, 1300-page second edition was published in 2007.
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- Monagle P, Chalmers E, Chan A, deVeber G, Kirkham F, Massicotte P, Michelson AD. Antithrombotic therapy in neonates and children: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008;133:887-968
- Frelinger AL, Furman MI, Linden MD, Li Y, Fox ML, Barnard MR, Michelson AD. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway. A 700-patient study of aspirin resistance. Circulation 2006;113:2888-2896
- Michelson AD, Barnard MR, Hechtman HB, MacGregor H, Connolly RJ, Loscalzo J, Valeri CR. In vivo tracking of platelets: Circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function. Proceedings of the National Academy of Sciences, U.S.A. 1996;93:11877-11882
- Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. Journal of Clinical Investigation 1996;97:979-987
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