 |
|
|
| Daniel S. Kohane, MD, PhD |
 |
 |
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Department
|
Anesthesiology
|
|
Hospital Title
|
Principal Investigator
|
|
Academic Title
|
Associate Professor of Anesthesiology
|
|
Phone
|
617-355-7327
|
|
Fax
|
617.730.0453
|
|
Email
|
Daniel S. Kohane
|
|
Location
|
300 Longwood Avenue
Boston
MA 02115
|
 |
 |
|
|
|
|
|
|
The unifying theme in our research is drug delivery and biomaterials. In this multidisciplinary field, the specific application is less important than the development of an approach or set of approaches. The skilled practitioner applies engineering principles, biology, and knowledge of biomaterials to achieve a given goal. While addressing specific disease states is important, the thrust of research is to create methods by which drugs can be delivered to a range of sites in a variety of circumstances, or by which materials can be developed or adapted for biomedical uses.
|
|
|
|
|
|
Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Children's Hospital Boston) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Children's Hospital Boston). He is currently a Senior Associate in Pediatric Critical Care at Children's Hospital Boston at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery. He is also a senior associate in the laboratory of Prof. Robert Langer at the Massachusetts Institute of Technology.
|
|
|
|
|
- Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NGM, Berde CB, Langer RS: Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain 2003; 104: 415-421
- Haining WN, Anderson DG, Little SR, von Berwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS: pH-triggered microparticles for peptide vaccination. J. Immunol. 2004; 174: 2578-2585
- Yeo Y, Ito T, Bellas E, Highley CB, Marini R, Kohane DS: In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing post-surgical adhesions. Ann Surg 2007; 245: 819-824
- Ito T, Fraser IP, Yeo Y, Highley CB, Bellas E, Kohane DS: Anti-inflammatory function of an in-situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials 2007; 28: 1778-1786
- Zumbuehl A, Ferreira L, Kuhn D, Asthashkina A, Long L, Yeo Y, Iaconis T, Ghannoum M, Fink GR, Langer R, Kohane DS: Antifungal hydrogels. Proc Natl Acad Sci 2007; 104: 12994-8
- Hudson SP, Padera RF, Langer R, Kohane DS: Biocompatibility of mesoporous silicates. Biomaterials 2008; 29: 4045-4055
- Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS: A drug-eluting contact lens. IOVS 2009; (in press)
- Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS: Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci 2009; (in press)
|
|
|
|
|
|
Our research focuses on a wide range of medical problems including pain, peritoneal and other adhesions, surgical glues, vaccine vehicles, intracranial drug delivery, intra-articular drug delivery, patient-controlled drug delivery systems, antifungal surfaces, intracellular delivery of enzymes, ocular and trans-tympanic drug delivery, corneal prostheses, and others. We have employed microparticles and nanoparticles, including polymer systems, liposomes, mesoporous silicates, and others; hydrogels; and combination systems. Other interests include microfluidics, tissue engineering, and surface modification. We have applied our approach in food, beverage, and agricultural research as well.
|
|
|
|
|
|
Most of our research is very oriented toward clinical application.
|
|
|
|
|
|
|
|
|
|
|
