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Department
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Endocrinology
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Hospital Title
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Research Associate
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Academic Title
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Assistant Professor of Pediatrics
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Phone
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(617) 919 4684
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Fax
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(617) 730 0244
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Email
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Umut Ozcan
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Location
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300 Longwood Avenue
Boston
MA 02115
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The primary aim of Ozcan laboratory is to delineate the molecular mechanisms of endoplasmic reticulum (ER) stress originated pathologies in obesity. The two main focus areas are insulin and leptin receptor signaling and its crosstalk with the unfolded protein reponse pathway. Dr. Ozcan's group employ a multi-disciplinary approach that draws on mouse genetics, endoplasmic reticulum physiology & pathophysiology, biochemistry, chemical biology and proteomics to identify key metabolic pathways that determine the cell?s response to physiologic and pathophysiologic ER stress. The ultimate goal of this integrated approach is to unravel the potential therapeutic targets in unfolded signaling pathway in order to manipulate cellular energy metabolism in obesity and find a cure for treatment of obesity and obesity related diseases.
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Umut Ozcan received his MD degree from the University of Istanbul. He completed his research training at the Joslin Diabetes Center and Harvard School of Public Health.
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- Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr, Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metabolism. 2009 Jan 7;9(1):35-51.
- Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis. Molecular Cell. 2008 Mar 14;29(5):541-51.
- Ozcan U, Yilmaz E, Ozcan L, Fruhashi M, Vallancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical Chaperones Reduce Endoplasmic Reticulum Stress and Restore Glucose Homeostasis In a Mouse Model of Type-2 Diabetes. (Science. 2006 Aug 25;313(5790):1137-40).
- Ozcan U*, Cao Q*, Yilmaz E, Lee AH, Iwaksohi NN, Ozdelen E, Tuncman G, Gorgun CZ, Glimcher LH and Hotamisligil GS. Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes. (Science. 2004 Oct 15; 306(5695):457-61).
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