Arin K. Greene, MD, MMSc

Research Overview

Vascular anomalies:
Research and study into the possibility of proliferating endothelium during times of growth, as well as possible predictor variables including anomaly type, history of treatment, and patient age. Also, a current 'Recurrence of Vascular Anomalies' study hopes to better document the recurrence rate for all types of vascular malformations, as well as the rate of progression during specific time frames.

Cranioplasty:
Cranioplasty in young children is difficult because of limited autologous donor sites and the reluctance to use alloplastic materials in the growing skeleton. Our research has shown that particulate cranial bone graft harvested from infants effectively prevents, as well as treats, calvarial defects. We are translating our clinical findings to an animal model to compare angiogenesis and healing between particulate bone graft, other sources of autologous bone, and alloplastic materials.

About Arin K. Greene

Arin K. Greene received an MD from the University of Illinois School Of Medicine and an MMSc in vascular anomalies from Harvard Medical School. He completed an internship and residency in general surgery at Beth Israel Deaconess Medical Center, followed by a plastic surgery residency with Harvard Plastic Surgery Training Program. Dr. Greene has completed two fellowships with Children's including a research fellowship in the Department of Surgery and a fellowship with the Craniofacial & Pediatric Plastic Surgery program.

Key Publications

• Greene AK, Puder M, Roy R, Arsenault D, Kwei S, Moses MA, Orgill DP. Microdeformational would therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of three debilitated patients. Annals of Plastic Surgery 2006; 56: 418-422.
   
• Greene AK, Proctor M, Mulliken JB, Rogers GF. Primary grafting with autologous cranial particulate bone prevents osseous defects following fronto-orbital advancement. Plastic and Reconstructive Surgery 2007; 120: 1603-1611.
   
• Greene AK, Proctor M, Mulliken JB, Rogers GF. Pediatric cranioplasty using particulate calvarial bone graft. Plastic and Reconstructive Surgery 2008; 122: 563-571.

Honors, Awards and Grants

• 2000-2003
  PI, Howard Hughes Medical Institute, Angiogenic control of organ mass
   
• 2008-2009
  PI, American Cleft Palate-Craniofacial Association, Determining the effectiveness of autologous calvarial particulate bone graft onlay cranioplasty
   
• 2008-2009
  PI, American Society of Plastic Surgeons, Determining the effectiveness of autologous calvarial particulate bone graft onlay cranioplasty
   
• 2008-2010
  Children's Hospital Boston Junior Faculty Career Development Award, Growth of vascular malformations: determining the role of the endothelium

The Department of Pediatric Plastic Surgery Research Laboratory