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Department
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Gastroenterology/Nutrition
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Hospital Title
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Staff Scientist
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Academic Title
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Assistant Professor
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Phone
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617-919-4852
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Fax
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Email
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Jonathan Kagan
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Location
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Enders Building, Room 730.2
300 Longwood Avenue
Boston MA 02115
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Dr. Kagan's research focuses on understanding the organization of signal transduction pathways within cells of the mammalian immune system. As a model, he focuses his attention on members of the Toll-like Receptor family (TLR) family of proteins. TLRs play a critical role in the detection and elimination of infectious microorganisms that enter the human body. Signaling events that occur downstream from TLR-mediated microbial detection are the primary source of interest to the Kagan lab. Understanding the assembly and regulation of these signaling complexes is directly relevant to the study of human infections, autoimmunity and cancer.
Goals of Dr. Kagan's research include:
- Understanding the organization and recruitment of signaling proteins to active Toll-like Receptors in professional antigen presenting cells
- Understanding the molecular mechanisms governing crosstalk between functionally related signaling pathways in the human immune system
- Understanding how microbial pathogens can manipulate TLR signaling to promote their colonization and dissemination
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Jonathan Kagan trained with Craig Roy, receiving his Ph.D. in Microbial Pathogenesis from Yale University. He then performed postdoctoral training with Ruslan Medzhitov in the Immunobiology Department at the Yale University School of Medicine.
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- Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008; Feb 24; [Epub ahead of print]
- Kagan JC and Medzhitov R. Phosphoinositide mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006; 125(5):943-955.
- Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nature Immunology. 2006; 7(1):49-56.
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