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Department
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Neurology
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Hospital Title
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Senior Associate in Neurology
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Academic Title
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Associate Professor of Neurology
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Phone
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617-355-6962
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Fax
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617-730-0243
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Email
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Paul Rosenberg
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Location
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300 Longwood Avenue
Enders-3
Boston
MA 02115
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Paul Rosenberg's current research focuses on two areas--disorders of the brain and sleep disturbances. In the first line of research, he seeks to understand the mechanisms of brain injury in order to provide a rational basis for preventing and treating important neurological disorders and diseases. In pursuit of this goal, he is working to characterize pathways of cell death in neurons and oligodendrocytes. He is currently investigating how expression and function of the glutamate transporter GLT1 is regulated at normal synapses and how GLT1 function is compromised in neurodegenerative diseases. In the second, he is investigating the biochemical and molecular basis of behavioral state regulation to provide the foundation for developing better pharmacological treatments for sleep disorders. To this end, he is currently investigating the role of nitric oxide and adenosine in regulating behavioral states.
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Paul Rosenberg received his MD and PhD degrees from Albert Einstein College of Medicine. He completed an internship at University Hospital, Boston, a neurology residency through the Harvard-Longwood Neurological Training Program, and a fellowship at Children's Hospital Boston.
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- Chen, W. Mahadomrongkul, V., Berger, U.V., Bassan, M., DeSilva, T., Tanaka, K., Irwin, N., Aoki, C., Rosenberg, P.A. 2004. The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. Journal of Neuroscience. 24: 1136-1148.
- Baud, O., Greene, A.E., Li, J., Wang, H., Volpe, J.J., and Rosenberg, P.A. 2004. Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. Journal of Neuroscience. 24: 1531-1540
- Rosenberg PA, Le M, Li Y. 2000. Nitric oxide stimulated increase in extracellular adenosine accumulation in rat forebrain neurons in culture is associated with ATP hydrolysis and inhibition of adenosine kinase activity. Journal of Neuroscience. 20: 6294-6301
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