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Department
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Neurosurgery
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Hospital Title
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Staff Neurosurgeon
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Academic Title
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Assistant Professor in Surgery
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Phone
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617-355-8414
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Fax
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617-730-0906
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Email
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Edward Smith
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Location
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300 Longwood Avenue
Boston MA 02115
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Dr. Smith is currently engaged in basic science research on primary brain tumors and cerebrovascular disease. His research is primarily centered on obtaining an increased understanding of the molecular mechanisms of tumorigenesis and angiogenesis in the central nervous system. This work has included the use of basic science and translational studies investigating adult and pediatric brain tumors, moyamoya disease and cerebral vascular malformations. This research has implicated the class of extracellular matrix proteins called matrix metalloproteinases (MMPs) in the advent and progression of several disease states of the central nervous system, including brain tumors, moyamoya and vascular malformations.
One of the major research interests of Dr. Smith, in conjunction with the Moses lab, is the study of pediatric cerebral arteriovenous malformations (AVMs). A number of specific projects related to this area have been generously supported by the Lucas Warner AVM research fund. This support has resulted in exciting discoveries relevant to the diagnosis, understanding and treatment of these challenging lesions. His research has been supported by funding from several other sources, including the NIH, and is carried out in collaboration with a number of investigators in associated fields, particularly Marsha Moses, PhD, of the Vascular Biology Program.
Goals of Dr. Smith's work include:
- development of a panel of non-invasive biomarkers for the detection and follow-up of neurosurgical disease
- development of novel therapeutic interventions for neurosurgical disease based on regulation of vascular stability
- investigation of the molecular mechanisms regulating tumorigenesis and angiogenesis in the central nervous system
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Dr. Smith received an MD from Columbia University. He completed a neurosurgery residency at Massachusetts General Hospital and a fellowship in pediatric neurosurgery at Children's Hospital Boston.
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- Smith ER, Manfredi M, Scott RM, Black PM, Moses MA, Case of a recurrent craniopharyngioma used to illustrate the potential utility of urinary matrix metalloproteinases as non-invasive biomarkers. (In press, Neurosurgery)
- Roach ES, (Chair), Golomb M, Adams R, Biller, Daniels JS, deVeber G, Ferriero D, Ichord R, Jones B, Kirkham F, Scott RM, Smith ER, Guidelines for the Management of Cerebrovascular Disorders in Infants and Children: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association. (In press)
- Jea A, Smith ER, Robertson R, Scott RM Moyamoya syndrome associated with Down syndrome - Outcome following surgical revascularization Pediatrics, 2005 Nov;116(5):e694-701.
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