Program in Genomics

Bioinformatics Core

The Bioinformatics Core provides the computational infrastructure to facilitate efficient and seamless informational cross-talk between the different Cores of the Genomics Program. Additionally, we offer individualized support and collaboration in the design of integrative genomics studies and data analysis-interpretation with study projects using any Genomics Core. Our scope of work includes:

• Reviewing all relevant statistical and bioinformatical considerations prior to the implementation of multi-factorial genome-scale studies.
• Maintaining a secure, web-accessible and MIAME-compliant database for molecular data (e.g., genotype, RNA expression profile) storage, curation and basic data analysis.
• Implementing state-of-the-art data analyses and mathematical models of molecular data (genome, transcriptome, proteome, phenome) to optimally address the specific aims of respective study projects using the Genomics Cores.
• Taking an integrative genomics approach to data analysis. For example, when and where relevant, external bio-data from the public domain (e.g., NIH-NCBI's Gene Expression Omnibus and EMBL-EBI's ArrayExpress) will be included in our analyses, serving both as rational means of in silico validation (via independent test datasets) and for prioritizing candidate molecules/pathways for further functional validation in the laboratory.
• Scientific collaborations with study projects using the Genomics Cores.