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Brendan Harley, Sc.D. - Research Fellow
Education
2000 S.B. Harvard University
2002 S.M. Massachusetts Institute of Technology
2006 Sc.D. Massachusetts Institute of Technology
Publications
Book Chapters
  • B.A. Harley and I.V. Yannas in R. Lanza, R. Langer, and J.P. Vacanti (eds.), "In Vivo Synthesis of Tissues and Organs," in Principles of Tissue Engineering, 3rd Edition, New York: Elsevier, 2007.
  • B.A. Harley and I.V. Yannas in J.G. Webster (ed.) "Skin: Tissue Engineering for Regeneration," in The Encyclopedia of Medical Devices and Instrumentation, 2nd Edition, New York: Wiley, 2006.
Peer-Reviewed Journal Articles
  • Harley BA, Spilker MH, Wu JW, Asano KA, Hsu H-P, Spector M, Yannas IV. (2004) Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps. Cells Tissues Organs. 176(1-3):153-165.
  • O'Brien FJ, Harley BA, Yannas IV, Gibson LJ. (2004) Influence of freezing-rage on pore structure in freeze-dried collagen-GAG scaffolds. Biomaterials. 25(6):1077-1086.
  • O'Brien FJ, Harley BA, Yannas IV, Gibson LJ. (2005) The effect of pore size and structure on cell adhesion in collagen-GAG scaffolds. Biomaterials. 26(4):433-441.
  • Harley BA, Hastings AZ, Yannas IV, Sannino A. (2005) Fabricating tubular scaffolds with a radial pore size gradient by a spinning technique. Biomaterials. 27(6):866-874.
  • Farrell E, O'Brien FJ, Byrne E, Doyle P, Fischer J, Yannas IV, Harley BA, O'Connell B, Prendergast PJ, Campbell VA. (2006) A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiaion along the osteogenic and chrondrogenic routes. Tissue Engineering. 12(3):459-468.
  • Harley BA, and Yannas, IV. (2006) Induced peripheral nerve regeneration using scaffolds. Minerva Biotecnologica. 19(2):97-120.
  • O'Brien FJ, Harley BA, Waller MA, Yannas IV, Gibson LJ, Prendergast PJ. (2007) The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering. Technol. Health Care. 15(1):3-17.
  • Harley BA, Leung JH, Silva ECCM, Gibson LJ. (2007) Mechanical characterization of collagen-glycosaminoglycan scaffolds. Acta Biomaterialia. 3(4):463-474.
  • Harley BA, Freyman TM, Wong MQ, Gibson LJ. (2007) A new technique for calculating individual dermal fibroblast contractile forces generated within collagen-GAG scaffolds. Biophys. J. In Press.
  • Harley BA, Gibson LJ. (2007) In vivo and in vitro applications of collagen-GAG scaffolds. Chemical Engineering Journal. In Press.
Company
www.orthomimetics.com
Co-Founder, OrthoMimetics, 2005
OrthoMimetics (OM) specializes in the design, development, and manufacture of implantable biomaterials for the regenerative repair of cartilage, ligament, and tendon injuries, a major cause of the pathological degeneration that leads to joint replacement. The scaffold-based biomaterials developed by OM provide a practical, reproducible, and adaptable means for improving the outcome of existing orthopedic surgical treatments for trauma, sports injuries, and early osteoarthritits.
OrthoMimetics is a privately held company formed as the first spin-out venture from the Cambridge-MIT Institute (CMI) that is currently headquartered in Cambridge, U.K.
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