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News/ Publications
 
In the News
New Director of Orthopedic Research
Ortho Times, Dec 2006 (pdf)

Names and Faces
Pediatric Views, Jun 2006

The World's Densest Bones
The Scientist, Oct 2006| Vol 20, Issue 10

Of Joints and Genes
HHMI Bulletin, Jun 2003| Vol 16, No. 2

Select Peer Reviewed Publications
  1. The role of lubricin in the mechanical behavior of synovial fluid. Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS. Proc Natl Acad Sci 2007 Apr; 104(15):6194-9.
  2. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. Sawakami K, Robling AG, Ali M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML, Turner CH. J Biol Chem 2006 Aug; 281(33):23698-711.
  3. Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families. Bukulmez H, Matthews AL, Sullivan CM, Chen C, Kraay MJ, Elston RC, Moskowitz RW, Goldberg VM, Warman ML. Arthritis Res Ther 2006;8(1):R25. Epub 2006 Jan 3.
  4. Somatic mosaicism in a male with an exon skipping mutation in PDHA1 of the pyruvate dehydrogenase complex results in a milder phenotype. Okajima K, Warman ML, Byrne LC, Kerr DS. Mol Genet Metab 2006 Feb;87(2):162-8. Epub 2006 Jan 18.
  5. Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y,Laxer R, Goldbach-Mansky R, Warman ML.???J Biol Chem. 2005. Jul 5;(Epub)
  6. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart M, Wang H, Warman ML, Carpten JD. J Clin INvest 2005 Mar; 115(3):622-631.
  7. WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Kutz WE, Gong Y, Warman ML. Mol Cell Biol 2005 Jan;25(1):414-421.
  8. Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Ai M, Holmen SL, Van Hul W, Williams BO, Warman ML. Mol Cell Biol 2005 Jun;25(12):4946-55.
  9. Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. Bartels CF, Bukulmez H, Padayatti P, Rhee DK, van Ravenswaaij-Arts C, Pauli RM, Mundlos S, Chitayat D, Shih LY, Al-Gazali LI, Kant S, Cole T, Morton J, Cormier-Daire V, Faivre L, Lees M, Kirk J, Mortier GR, Leroy J, Zabel B, Kim CA, Crow Y, Braverman NE, van den Akker F, Warman ML. Am J Hum Genet 2004 Jul;75(1):27-34.
  10. Cohen syndrome in the Ohio Amish. Falk MJ, Feiler HS, Neilson DE, Maxwell K, Lee JV, Segall SK, Robin NH, Wilhelmsen KC, Kolehmainen J, Lehesjoki AE, Wiznitzer M, Warman ML. Am J Med Genet 2004 Jul 1;128A(1):23-8.
  11. Autosomal dominant acute necrotizing encephalopathy maps to 2q12.1-2q13. Neilson DE, Feiler HS, Wilhelmsen KC, Lynn A, Eiben RM, Warman ML . Ann Neurol 2004 Feb; 55(2):291-4.
  12. Autosomal dominant acute necrotizing encephalopathy. Neilson DE, Eiben RM, Waniewski S, Hoppel CL, Warman ML, Kerr DS. Neurology 2003 Jul22;61(2):226-30.
  13. Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density. Van Wesenbeeck L, Cleiren E, Gram J, Beals RK, Benichou O, Scopelliti D, Key L, Renton T, Bartels C, Gong Y, Warman ML, De Vernejoul MC, Bollerslev J, Van Hul W. Am J Hum Genet 2003 Mar;72(3):763-71.
  14. Intravenous bisphosphonate therapy in children with osteogenesis imperfecta. Falk MJ, Heeger S, Lynch K, DeCaro K, Bohach D, Warman ML. Pediatrics 2003 Mar;111(3):573-8.
  15. The mutational spectrum of Brachydactyly type C. Everman DB, Bartels CF, Yang Y, Yanamandra N, Goodman FR, Mendoza-Londono JR, Savarirayan R, White SM, Graham JM Jr, Gale RP, Svarch E, Newman WG, Kleckers AR, Francomano CA, Govindaiah V, Singh L, Morrison S, Thomas JT, Warman, ML. Am J Med Genet. 2002 Oct 15;112(3):291-6.
  16. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML. Cell 2001 Nov 16;107(4):513-23.
  17. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. Jepsen KJ, Pennington DE, Lee, YL, Warman M, Nadeau J. J. Bone Miner. Res 16:1854-1862.
  18. Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Marcelino J, Sciortino CM, Romero MF, Ulatowski LM, Ballock RT, Economides AN, Eimon PM, Harland RM, Warman ML. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11353-8. Epub 2001 Sep 18.
  19. Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Truett GE, Heeger P, Mynatt RL, Truett AA, Walker JA, Warman ML. Biotechniques. 2000 Jul;29(1):52, 54.
  20. Brachydactyly type B: Clinical description, genetic mapping to chromosome 9q, and evidence for a shared ancestral mutation. Gong Y, Chitayat D, Kerr B, Chen T, Babul-Hirji R, Pal A, Reiss M, Warman ML. Am J Hum Genet 1999 64:570-577.
  21. Heterozygous mutations in the gene encoding NOGGIN affect human joint morphogenesis. Gong Y, Krakow D, Marcelino J, Wilkin D, Chitayat D, Babul-Hirji R, Hudgins L, Cremers CW, Cremers FP, Brunner HG, Reinker K, Rimoin DL, Cohn DH, Goodman FR, Reardon W, Patton M, Francomano CA, Warman, ML. Nature Genet 1999 21:302-304.
  22. Mutations in the CCN family member WISP3 cause progressive pseudorheumatoid dysplasia. Hurvitz JR, Suwairi WM, Van Hul W, El-Shanti H, Superti-Furga A, Roudier J, Holderbaum D, Pauli RM, Herd JK, Van Hul EV, Rezai-Delui H, Legius E, Le Merrer M, Al-Alami J, Bahabri SA, Warman ML. Nature Genet 1999 23:94-98.
  23. CACP encodes a secreted proteoglycan that is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman, ML. Nature Genet 1999 24:319-322.
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