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Department
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Hematology/Oncology
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Hospital Title
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Academic Title
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Assistant Professor in Pediatrics
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Phone
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617-919-2508
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Fax
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617-730-0934
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Email
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Sung-Yun Pai
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Location
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Karp Family Research Laboratories
Room 08214
One Blackfan Circle
Boston, MA 02115
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The Pai laboratory focuses on the transcriptional regulation of T cell development and function. Using a conditional mouse model in which the transcription factor GATA-3 is deleted in the thymus, Dr. Pai showed that GATA-3 is required for the generation of CD4 + thymocytes and T cells. In addition, she showed that GATA-3 is necessary for the development of peripheral T cells into T helper type 2 (Th2) cells that are responsible for IL-4, IL5, IL-10 and IL-13 production. Her laboratory is currently working to define the GATA-3 transcriptional targets that drive CD4 T cell development. Such targets are expected to have important roles in CD4 T cell generation and survival, and thus could be used therapeutically to improve immune reconstitution in a variety of clinical states, such as in the post-hematopoietic stem cell transplantation setting.
The Pai laboratory is also enrolling patients on a clinical research protocol in which bone marrow samples from primary immunodeficiency patients are used to define and characterize naturally occurring blocks in T cell development. This novel approach to studying human immunodeficiency will allow her laboratory to discover new molecular defects responsible for aberrant T cell development.
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Dr. Pai received her MD degree with honors from Harvard Medical School in 1994. She trained in pediatrics at Children's Hospital in Boston from 1994 to 1997 and in pediatric hematology-oncology at Dana-Farber Cancer Institute/Children's Hospital Boston from 1998 to 2001.
She has been on staff at Children's Hospital and Dana-Farber Cancer Institute since 2001. As Associate Chief of Primary Immunodeficiency Disorders she evaluates patients with primary immunodeficiency for curative hematopoietic stem cell transplantation.
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- Pai SY, Kang BY, Sabadini A , Parisini E, Truitt ML, Ho IC. Distinct Structural Requirements of GATA-3 in the Regulation of Thymocyte and Th2 Cell Differentiation. J. Immunol 2008 Jan 15; 180 (2): 1050-1059.
- Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 Regulates the Development and Function of Invariant NKT Cells. J. Immunol. 2006 Nov 15; 177 (10): 6650-6659.
- Pai SY, DeMartiis D, Forino C, Cavagnini S, Lanfranchi A, Giliani S, Moratto D, Porta F, Imberti, L, Notarangelo LD, Mazzolari, E. Stem cell transplantation for the Wiskott-Aldrich syndrome: a single-center experience confirms efficacy of matched unrelated donor transplantation. Bone Marrow Transplant. 2006 Nov; 38 (10): 671-679.
- Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of Th2 cells. Proc Natl Acad Sci 2004; 101: 1993-1998.
- Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 2003; 19: 863-875.
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