Martha Murray, MD
| Department | Orthopedic Center |
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| Hospital Title | Principal Investigator | |
| Academic Title | Associate Professor in Orthopedic Surgery | |
| Phone | 617-355-7132 | |
| Fax | 617-730-0456 | |
| Martha Murray | ||
| Location |
300 Longwood Avenue Boston MA 02115 |
Research Overview
Dr. Murray's research focuses on the stimulation of healing of tissues inside joints, particularly the anterior cruciate ligament (ACL) and meniscus of the knee. Treatment of these injuries remains one of the most challenging problems facing orthopedic science today. These tissues have minimal intrinsic ability to repair or regenerate in the human and thus injuries of these tissues are often treated by excision of the injured tissue and sometimes replacement with autograft or allograft tissue. Unfortunately, these procedures lead to a high rate of premature osteoarthritis of the knee (as high as 80% at 14 years after an ACL tear).
Dr. Murray's lab studies the regenerative potential of the native tissues after injury, and have found that the cells in each of these tissues have great potential for proliferation, extra-cellular matrix production and migration if provided with the appropriate environment. The Murray lab has identified the premature loss of fibrin clot (secondary to the presence of plasmin in the synovial fluid) as the likely etiology of the failure of these tissues to heal. Work continues to focus on development of a substitute for fibrin clot, which allows healing of tissues within the joint to proceed the way healing of tissues outside the joint can.
Dr. Murray also specializes in the clinical care and surgical treatment of patients with knee injuries, including injuries of the ACL, meniscus, and cartilage. If you would like to schedule an appointment to see her, please call 617-355-3501.
About Martha Murray
Martha Murray received her master's degree in Materials Science and Engineering from Stanford University and her medical degree from the University of Pennsylvania. She completed a residency in orthopedic surgery at Harvard Medical School and fellowships in pediatric orthopedics and sports medicine at Boston Children's Hospital.
Key Publications
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Murray MM, Palmer M, Magarian E, Abreu E, Zurakowski D, Spindler KP, Fleming BC: Bone to bone fixation enhances functional healing of the ACL. Arthroscopy. 2010 Sep;26 (9 Suppl):S49-57. Epub 2010 Jun 11.
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Murray MM, Magarian EM, Harrison SL, Zurakowski D, and Fleming BC: The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am. 2010 Sep 1;92(11):2039-49.
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Fleming BC, Spindler KP, Palmer M, Magarian E, Murray MM: Collagen-platelet composites improve the biomechanical properties of healing ACL grafts in a porcine model. Am J Sports Med. 2009 Aug;37(8):1554-63. Epub 2009 Mar 31.
- Joshi SM, Mastrangelo AN, Fleming BC, Murray MM: Collagen-Platelet Composite Enhances Histologic Healing of the ACL. Am J Sports Med. 2009 Dec;37(12):2401-10.
Martha Murray's Curriculum vitae
Articles on PubMed.org authored or co-authored by Dr. Murray.
Clinical Care
Dr. Murray also specializes in the clinical care and surgical treatment of patients with knee injuries, including injuries of the ACL, meniscus, and cartilage. If you would like to schedule an appointment to see her, please call 617-355-3501.
