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Home
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Director's Letter
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History of the Program and Accomplishments
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Description of the Program
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Resources and Environment
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Children's Hospital
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Basic Research Faculty
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GI Cell Biology Laboratories
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Harvard Digestive Diseases Center
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Graduate Programs at Harvard & MIT
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Clinical Research Faculty
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Afdhal, Nezam H.
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Austin, S. Bryn
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Christiani, David C.
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Cook, E. Francis
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Duggan, Christopher P.
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Fawzi, Wafaie W.
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Finkelstein, Jonathan A.
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Gillman, Matthew W.
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Goldmann, Donald A.
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Gordon, Catherine M.
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Grand, Richard J.
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Grinspoon, Steven K.
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Jaksic, Tom
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Klibanski, Anne
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Lightdale, Jenifer R.
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Ludwig, David S.
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Newburger, Jane W.
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Nurko, Samuel S.
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Osganian, Stavroula K.
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Rufo, Paul A.
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Sands, Bruce E.
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Willett, Walter C.
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Center for Inflammatory Bowel Disease
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Master Degree Programs in Clinical Research
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General Clinical Research Centers
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Current Fellows
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Alumni
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Application Process and Forms
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Benefits
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Program Materials
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David C. Christiani, MD, MPH, MS
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Pulmonary Associates, Massachusetts General Hospital
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Harvard School of Public Health
665 Huntington Avenue
Boston, MA 02115
Telephone: 617-432-3323
Fax: 617-726-2932
Email: dchris@hohp.harvard.edu
Research Interests
My lab studies the interplay between environmental exposures, genetics and disease in human populations. This area of endeavor has been called molecular epidemiology. Examples of on-going studies where this approach is applied include: a case-control study of genetic susceptibility to lung cancer; a study of genetic susceptibility to severe infection, sepsis and acute lung injury; biomarkers of exposure, response and susceptibility to arsenic poisoning in Bangladesh; gene-environment interactions in brain neoplasms and leukemia in children and youths living in polluted areas of Taiwan; and a 20 year longitudinal study of organic dust and endotoxin exposure and relevant polymorphisms among a cohort of cotton textile workers in Shanghai, China. Since occupationally- exposed populations afford the opportunity to assess the earliest effects of exposure, we often develop and apply biomarker methodology in epidemiologic studies of these groups.
Selected Publications
Zhou W, Heist RS, Liu G, Asomaning K, Neuberg DS, Hollis BW, Wain JC, Lynch TJ, Giovannucci E, Su L, Christiani DC. Circulating 25-hydroxyvitamin d levels predict survival in early-stage non-small-cell lung cancer patients. J Clin Oncol. 2007 Feb 10;25(5):479-85.
Zhai R, Gong MN, Zhou W, Thompson TB, Kraft P, Su L, Christiani DC. Genotypes and haplotypes of VEGF gene are associated with higher ARDS Mortality and lower VEGF plasma levels. Thorax. 2007 Feb 8; [Epub ahead of print]
Yu CL, Wang SF, Pan PC, Wu MT, Ho CK, Smith TJ, Li Y, Pothier L, Christiani DC; Kaohsiung Leukemia Research Group. Abstract Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure. Am J Epidemiol. 2006 Aug 1;164(3):200-7. Epub 2006 Jun 5.
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