Research Lab

Lencer Laboratory

Publications

  • Wolf, A.A., M.G. Jobling, S. Wimer-Mackin, J.L. Madara, R.K. Holmes, and W.I. Lencer. 1998. Ganglioside structure dictates signal transduction by cholera toxin in polarized epithelia and association with caveolae-like membrane domains. J Cell Biol. 141:917-927.
     
  • Dickinson, B., K. Badizadegan, Z. Wu, J.C. Ahouse, X. Zhu, N.E. Simister, R.S. Blumberg, and W.I. Lencer. 1999. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal cell line. J. Clin. Invest. 104:903-911.
     
  • W.I. Lencer. 1998. Ganglioside structure dictates signal transduction by cholera toxin in polarized epithelia and association with caveolae-like membrane domains. J Cell Biol. 141:917-927.
     
  • Tsai, B., C. Rodighiero, W.I. Lencer, and T. Rapoport. 2001. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell. 104:937-948.
     
  • Rodighiero, C., B. Tsai, T.A. Rapoport, and W.I. Lencer. 2002. Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep. 3:1222-1227.
     
  • Spiekermann, G.M., P.W. Finn, E.S. Ward, J. Dumont, B.L. Dickinson, R.S. Blumberg, and W.I. Lencer. 2002. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med. 196:303-10.
     
  • Lencer, W.I., and B. Tsai. 2003. The intracellular voyage of cholera toxin: going retro. Trends Biochem Sci. 28:639-45.
     
  • Feng, Y., A.P. Jadhav, C. Rodighiero, Y. Fujinaga, T. Kirchhausen, and W.I. Lencer. 2004. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 5:596-601.
     
  • Kothe, M., Y. Ye, J.S. Wagner, H.E. De Luca, E. Kern, T.A. Rapoport, and W.I. Lencer. 2005. Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem. 280:28127-32.
     
  • Dickinson, B.L., S.M. Claypool, J.A. D'Angelo, M.L. Aiken, N. Venu, E.H. Yen, J.S. Wagner, J.A. Borawski, A.T. Pierce, R. Hershberg, R.S. Blumberg, and W.I. Lencer. 2008. Ca2+-dependent Calmodulin Binding to FcRn Affects Immunoglobulin G Transport in the Transcytotic Pathway. Mol Biol Cell. 19:414-423.
     
  • Saslowsky, D.E., N. Tanaka, K.P. Reddy, and W.I. Lencer. 2009. Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia. Faseb J. 23:259-70.