Postdoctoral fellow sasha.singh@childrens.harvard.edu

Sasha Singh obtained her BSc, MSc and PhD degrees from the University of Toronto. Her current projects focus on using quantitative mass spectrometry for in-depth protein characterization, including post-translational modification analysis.

Publications:

S. Singh*, J. Stavrinides*, D. Christendat, and D. Guttman. A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass. Mol Biol Evol. 2008 Oct: 25 (10):2221-32

S.A. Singh and D. Christendat. The DHQ-dehydroshikimate-SDH-shikimate-NADP(H) complex: insights into metabolite transfer in the shikimate pathway. Cryst. Growth Des. 2007; 7(11):215-2160

S.A. Singh and D. Christendat. Structure of Arabidopsis DHQ-SDH and implications on metabolic channeling in the shikimate pathway. Biochemistry. 2006 Jun 27; 45(25): 7787-96.

W. Sun*, S. Singh*, R. Zhang, J. Turnbull and D. Christendat. Crystal structure of prephenate dehydrogenase from Aquifex aeolicus: insights into the catalytic mechanism. Biol Chem. 2006 May 5; 281(18): 12919-28.

J. Bonvin, R. Aponte, M. Marcantonio, S. Singh, D. Christendat and J. Turnbull. Biochemical characterization of prephenate dehydrogenase from the hyperthermophilic bacterium Aquifex aeolicus. Protein Sci. 2006 Jun; 15(6): 1417-32.

S. Singh, S. Korolev, O. Koroleva, T. Zarembinski, F. Collart, A. Joachimiak and D.Christendat. Crystal Structure of a Novel Shikimate Dehydrogenase from Haemophilus influenzae. J Biol Chem. 2005 Apr 29; 280(17): 17101-8.

C.S. Hardtke, W. Ckurshumova, D.P. Vidaurre, S.A. Singh, G. Stamatiou, S.B. Tiwari, G. Hagen, T.J. Guilfoyle and T. Berleth. Overlapping and non-redundant functions of the Arabidopsis auxin response factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4. Development 2004 Mar; 131(5): 1089-1100.