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Welcome to the home page of the Steen & Steen Lab
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The research in our laboratory is focused on four different areas:
The development of novel and improved mass spectrometric and proteomic methods for the analysis of complex protein mixtures and the detailed characterization of proteins within these mixtures, including the analysis of post-translational protein modifications and the quantitation of protein abundances.
Development of instrument platforms for the detection and identification of disease-markers with special emphasis on pediatric diseases.
The use of mass spectrometry to identify mechanisms of cell cycle control during neurogenesis.
Development and applications of strategies to solve systems biological questions and problems at the proteome level.
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To achieve our goals we use proteomic and mass spectrometric technology in addition to biochemistry and molecular biology approaches, cell culture systems and animal models, including the mouse, the rat, and the African clawfrog.
The lab is equipped with 4 high-end research grade tandem mass spectrometers complemented by various peripherals, wet lab space and a complete (bio)IT infrastructure.
The lab is run jointly by Judith A. J. Steen who holds an appointment in the Neurobiology Department of Children's Hospital and Hanno Steen, appointed in the Pathology Department of Children's Hospital. The research lab is closely associated with the Proteomics Center @ Children's Hospital Boston that offers various services to the researchers within Children's Hospital and the outside research community. For further inquiries, please visit the webpage of the Proteomics Center.
For further information, please contact:
Judith A. J. Steen, Ph.D.
Children's Hospital Boston
F. M. Kirby Center for Neurobiology
Center for Life Science, Room 12030
3 Blackfan Circle
Boston, MA 02115
Tel: +1-617-919-2450
Fax: +1-617-730-2771
e-mail: judith.steen(AT)childrens.harvard.edu
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Hanno Steen, Ph.D.
Children's Hospital Boston
Department of Pathology
John F. Enders Research Laboratories, Suite 1130
320 Longwood Avenue
Boston, MA 02115
Tel: +1-617-919-2629
Fax: +1-617-730-0168
email: hanno.steen(AT)childrens.harvard.edu
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| 360 degree view of the proteomics/mass spectrometry laboratory |
Virtual Tour of the Proteomics Laboratory
The new Proteomics Center at Children's Hospital Boston is home to a host of slick instruments. This tour of the center's main lab space gives descriptions of several of these, including the new FT-ICR mass spectrometer. (QuickTime plugin required. If your computer does not have QuickTime, you can download the free plugin.)
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