Keith Solomon's research is focused on lipid raft membrane microdomains. Lipid rafts are liquid-ordered, detergent-resistant membrane domains that contain high accumulations of cholesterol. Solomon and colleagues have been engaged in pioneering research on the function and organization of lipid rafts in lymphocytes, macrophages, osteoblasts, pericytes, and smooth muscle cells.

Recently, the Solomon laboratory has been exploring the role of cholesterol and lipid rafts as membrane platforms for signal transduction mechanisms that mediate cell growth, survival, and a variety of other processes relevant to cancer. The researchers are particularly interested in how lipid rafts enhance the ability of prostate cancer cells to resist pro-apoptotic signals in vitro and in the growth of prostatic tumors in vivo.