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Department
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Neurology
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Hospital Title
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Research Associate
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Academic Title
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Professor of Neurology
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Phone
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617-919-2257
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Fax
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617-730-1953
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Email
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Xi He
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Location
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300 Longwood Avenue
Enders-461.2
Boston MA 02115
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Xi He focuses on molecular mechanisms that govern vertebrate embryogenesis and growth regulation, in particular the signaling mechanism employed by the Wnt family of secreted growth factors. The Wnt/beta-catenin signal transduction pathway plays a critical role in axis formation and head versus trunk induction during early vertebrate embryogenesis. This pathway is also pivotal in human carcinogenesis because several key Wnt signaling components are encoded by human oncogenes or tumor suppressor genes. He and colleagues are investigating key components in different Wnt signaling pathways, and on the mechanism by which the signaling specificity is governed. They are also studying the mechanism of early neural development and Wnt regulation in the central nervous system.
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Xi He received his PhD degree at the University of California, San Diego. He completed a postdoctoral fellowship at the National Institutes of Health.
Dr. He is a Guest Professor at the School of Life Science and Engineering, Tsinghua University in Beijing, China. He is a Pew Scholar in Biomedical Sciences, Klingenstein Fellow in Neuroscience, and Keck Foundation Distinguished Young Scholar in Medical Research.
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- Tamai K, Zeng X, Chunming L, Zhang X, Harada Y, Chang Z, He X. A mechanism for Wnt coreceptor activation. Molecular Cell 2004; 13:149-56.
- He X, Semenov M, Tamai K, Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/{beta}-catenin signaling: Arrows point the way. Development 2004;131(8):1663-1677.
- Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X. The Wnt antagonist Dickkopf 1 is a ligand for low density lipoprotein receptor related proteins. Curr Biol 2001;26:951-961.
- He, X. Antagonizing Wnt and FGF receptors: an enemy from within (the ER). Cell 2005 120, 156-158.
- Semenov M, Tamai K and He X. SOST is a ligand for LRP5/LRP6 and an inhibitor of Wnt signaling. J. Biol. Chem.,2005, 280, 26770-26775.
- Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J and He X. A dual-kinase mechanism for Wnt coreceptor phosphorylation and activation. Nature, 2005, 438, 873-877.
- Zhang X, He X, Fu XY, Chang ZJ. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. J. Cell Sci., 2006, 119:1053-1062.
- Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J, Rychahou PG, Yang VW, He X, Evers BM, and Liu CM. Novel crosstalk of KLF and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol. Cell Biol., 2006, 26:2055-2064.
- He X and Axelrod J. A WNTer wonderland in Snowbird. Development, 2006, 133, 2597-2603.
- Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, Macdougald OA, You M, Williams BO, Guan KL. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth. Cell, 2006,126, 955-968.
- He X. Unwinding a path to nuclear beta-catenin. Cell, 2006, in press.
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