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Department
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Hematology/Oncology
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Hospital Title
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Associate Chief, Division of Hematology/Oncology
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Academic Title
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Associate Professor of Pediatrics
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Phone
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617-919-2139
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Fax
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617-730-0934
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Email
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Ellis Neufeld
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Location
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300 Longwood Avenue
Enders-7
Boston MA 02115
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Dr. Neufeld's laboratory studies candidate genes for inherited blood disorders. His group elucidated the thiamine transporter gene, SLC19A2, as the cause of the syndrome of thiamine-responsive megaloblastic anemia (TRMA) with diabetes and deafness. Other recent discoveries include identification of a novel sickling hemoglobin (Hb Jamaica Plain), and the finding that the GATA1 gene can cause X-linked gray-platelet syndrome. Clinical research areas of interest to Dr. Neufeld and his colleagues include Immune Thrombocytopenic Purpura (ITP), hemophilia and thalassemia.
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Ellis Neufeld received his MD and PhD degrees from Washington University in St. Louis. He completed training in Pediatrics, Hematology and Medical Genetics at Children's Hospital, Boston and Dana Farber Cancer Institute.
He is presently Associate Chief of the Division of Hematology/Oncology at Children's Hospital, Boston, and Associate Professor of Pediatrics at Harvard Medical School. He directs the Boston Hemophilia Center, and the thrombosis service at Children's Hospital. He has published more than 80 papers, related to his research interests including clinical trials in hemophilia, ITP and thalassemia, and laboratory studies of candidate genes for inherited blood disorders. Dr. Neufeld is the Principal Investigator for the Harvard Blood Scholars, a collaborative effort of all the Harvard hematology training programs sponsored by a K12 grant from NHLBI, aimed at training the next generation of physician scientists in hematology.
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- Boros LG, Steinkamp MP, Fleming JC, Lee WNP, Cascante M, Neufeld EJ. Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA). Blood 2003; 102: 3556-3561.
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Geva A, Clark JJ, Zhang Y, Popowicz A, Manning JM, Neufeld EJ. Hemoglobin Jamaica Plain?A Dominant Sickling Hemoglobin with Reduced Oxygen Affinity. NEJM 351;15:40-46 (2004).
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Bennett CM, Rogers ZR, Kinnamon DD, Bussel JB, Mahoney DH, Abshire TC, Sawaf H, Moore TB, Loh ML, Glader BE, McCarthy MC, Mueller BU, Olson TA, Lorenzana AN, Mentzer WC, Buchanan GR, Feldman HA, Neufeld EJ. Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. Blood. 2006; 107(7):2639-42.
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