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| Examining asthma in a live mouse. |
Our laboratory focuses on the study of subpopulations of human and murine CD4+ (helper) T cells, which play a central role in the regulation of the immune system. CD4+ T cells have multiple functions, but little is known about mechanisms that selectively activate one function over another. Since the coordinated expression of restricted profiles of lymphokines appears to be the major mechanism for the regulation of these diverse functions, we are examining the cellular, molecular and genetic mechanisms that regulate lymphokine synthesis in CD4+ T cells.
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