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  Children's Hospital Research  Children's Hospital Labs
Matthew M. Heeney, MD  Children's logo  Harvard logo
 Matthew M. Heeney, MD
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   Department  Hematology/Oncology
   Hospital Title  Director, Hematology Clinic; Clinical Director, Sickle Cell Program
   Academic Title  Instructor of Pediatrics
   Phone  617-355-7700
   Fax  617-730-0641
   Email  Matthew Heeney
   Location  300 Longwood Avenue
Boston MA 02115
Research Overview
Dr. Heeney conducts clinical research focused on sickle cell disorders and their treatment. He is currently the Principal Investigator of several clinical trials at Children's Hospital Boston, including the Children's Hospital Clinical Core of the Boston Sickle Cell Disease Research Network (SCD CRN).
Dr. Heeney is also interested in iron homeostasis in humans. He is investigating the genetic basis inherited disorders of iron deficency.

Goals of Dr. Heeney's work include: to improve the understanding of the pathophysiology and treatment of sickle cell anemia through multicenter clinical trials and to elucidate the genetic basis of iron deficiency.
About Matthew Heeney
Dr. Heeney received his MD at the University of Calgary, Alberta, completed his residency at Montreal Children's Hospital, McGill University, and a pediatric hemotology/oncology fellowship at Duke University.
Key Publications
  • Heeney MM. Howard TA. Zimmerman SA. Ware RE. UGT1A Promoter Polymorphisms Influence Bilirubin Response Hydroxyurea Therapy in Sickle Cell Anemia. Journal of Laboratory and Clinical Medicine. 141(4): 279-282, 2003.

  • Heeney MM. Whorton MR. Howard TA. Johnson CA. Ware RE. Chemical and Functional Analysis of Hydroxyurea Oral Solutions. Journal of Pediatric Hematology/Oncology. 26 (3): 179-184, 2004.

  • Heeney MM. Andrews NC. Iron Homeostasis and Inherited Iron Overload Disorders: An overview. Hematology/Oncology Clinics of North America. 18(6): 1379-403, 2004.

  • Finberg KE. Heeney MM. Campagna DR. Aydinok Y. Pearson HA. Hartman KR. Mayo MM. Samuel SM. Strouse JJ. Markianos K. Andrews NC. Fleming MD. Mutations in TMPRSS6 cause iron-refractory iron deficiency Anemia (IRIDA). Nature Genetics. 2008; 40(5): 485-682.

  • Heeney MM. Ware RE. Hydroxyurea for Children with Sickle Cell Disease. Pediatric Clinics of North America 2008; 55(2):483?501.
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