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  Children's Hospital Research  Children's Hospital Labs
Michael Klagsbrun, PhD  Children's logo  Harvard logo
 Michael Klagsbrun, PhD
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   Department  Vascular Biology Program
   Hospital Title  Senior Associate in Medicine
   Academic Title  Patricia K. Donahoe
Professor of Surgery
   Phone  617-919-2157
   Fax  617-730-0233
   Email  Michael Klagsbrun
   Location  300 Longwood Avenue
Karp-12
Boston MA 02115
Research Overview

Michael Klagsbrun has made major contributions to the field of growth factors and their receptors, particularly those that regulate the vascular system. He is credited with the first purifications of basic fibroblast growth factor (FGF-2), a potent angiogenesis factor, and of heparin-binding EGF-like growth factor (HB-EGF).

More recently, Dr. Klagsbrun's laboratory has purified several growth factor receptors. One of these, neuropilin, is a novel receptor for the angiogenesis factor VEGF that was originally described as a receptor for semaphorin, a molecule involved in regulating the direction of neuronal growth. These studies have suggested that similar molecular mechanisms regulate angiogenesis and neuronal guidance, both of which are networking processes.

About Michael Klagsbrun
Michael Klagsbrun received a PhD from the University of Wisconsin and spent his post-doctoral training as a commissioned Officer for the National Institute of Health's U. S. Public Health Service Laboratory of Biochemical Pharmacology. He has received two nine-year MERIT Awards from the National Cancer Institute.
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