Rheumatology Program | Autoinflammatory Diseases Clinic

The Autoinflammatory Diseases Clinic at Boston Children’s Hospital was established in 2014 to help with the diagnosis and treatment of patients with autoinflammatory diseases (often called periodic fever syndromes or recurrent fever syndromes). This clinic is one of the few centers in the country that specializes in the care of patients with these complex diseases.

Autoinflammatory diseases are members of a relatively new category of illnesses caused by disorders of one arm of the immune system. Many of these diseases are characterized by recurrent fevers, rash, chest and abdominal pain, and evidence of systemic inflammation on blood tests, findings that are often suggestive of infection even when none is present.

Most autoinflammatory diseases are genetic (inherited), start in childhood, and persist throughout adult life. Some diseases can be seen in several members of a family. Other autoinflammatory diseases appear to be acquired, perhaps due to the interplay of genetic and environmental factors, and can present at any time during childhood or adulthood.

Physicians in the Autoinflammatory Diseases clinic at Boston Children’s Hospital will work closely with other specialists, such as immunologists, infectious disease specialists, geneticists, dermatologists, hematologists, nephrologists and otolaryngologists who will see patients as necessary to provide comprehensive care to patients.

Who We Are

Dr. Fatma Dedeoglu, Dr. Jonathan Hausmann, and Dr. Catherine Biggs will staff the clinic every month. Because the clinic serves as an educational center for medical trainees to learn about these diseases, rheumatology fellows and pediatric residents will also participate in seeing patients. 

Who We Treat

The clinic specializes in treating patients with the following conditions:

  • Systemic-onset juvenile idiopathic arthritis (SoJIA)
  • Familial Mediterranean Fever (FMF) 
  • TNF receptor associated periodic syndrome (TRAPS) 
  • Hyperimmunoglobulin-D syndrome (Hyper-IgD syndrome, HIDS, also known as mevalonate kinase deficiency, MVK)
  • Cryopyrin-associated periodic syndromes (CAPS):
  • Familial cold autoinflammatory syndrome (FCAS, also known as familial cold urticaria)
  • Muckle-Wells syndrome
  • Neonatal onset multisystem inflammatory disease (NOMID, also known as CINCA) 
  • FCAS2 (NALP12)
  • Deficiency of the interleukin-1-receptor antagonist (DIRA)
  • Deficiency of the interleukin-36-receptor antagonist (DITRA)
  • Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) 
  • Blau syndrome 
  • Behcet’s Disease
  • Pyogenic sterile arthritis, Pyoderma gangrenosum, Acne (PAPA) 
  • Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome (SAPHO)
  • Chronic recurrent multifocal osteomyelitis (CRMO, also called chronic nonbacterial osteomyelitis, CNO)
  • Macrophage activation syndrome (MAS)
  • DADA2 (Deficiency of ADA2)
  • SAVI (STING-associated vasculopathy with onset in infancy)
  • Recurrent fevers of unknown cause