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Pain Treatment Services at Boston Children's Hospital, a division of the hospital's Department of Anesthesia, Perioperative and Pain Medicine and which operates the Mayo Family Pediatric Pain Rehabilitation Clinic (PPRC), was established in 1986 by Charles Berde, MD, PhD; Navil Sethna, MC, ChB; Bruce Masek, PhD; Claire McCarthy, MD, and their colleagues as the first multidisciplinary program in the world for pediatric acute and chronic pain management. Our program remains the most clinically active program of its kind in the world.
Innovations from our program over the past 3 decades include the following:
PPRC clinicians are involved in several clinical studies, such as:.
Brain fMRI for Children and Adolescents with Complex Regional Pain Syndromes (CRPS I and II)
Alyssa Lebel MD, Charles Berde MD PhD, Laura Chastain, David Borsook MD, Lino Becerra MD
CRPS in pediatric patients has several unique differences from the adult condition. Children can have recurrent episodes after apparent complete resolution of the signs and symptoms, sometimes with and sometimes without any inciting injury. Pediatric patients are unique among individuals with CRPS, as they are generally free of additional complicating neuropathic pain conditions and are developmentally more likely to demonstrate robust neuronal plasticity. CRPS remains, to date, clinically apparent but poorly defined at an anatomic and pathophysiologic level. Imaging of pain in pediatric patients with CRPS may provide a previously unavailable window into the central nervous system changes of challenging chronic pain disorders. Patients (9-20 years old) with CRPS affecting the lower extremity were recruited to the study. Subjects had pre-scanning thresholds measured to determine that the pain stimuli would be tolerable during the scanning. Mechanical stimuli (e.g. cold exposure, brushing) were applied to the affected region of the involved limb and the corresponding mirror region of the unaffected limb.
Other Pain Related Clinical Studies
To see a list of our most recent publications, please visit: Department Publications
The future of pediatrics will be forged by thinking differently, breaking paradigms and joining together in a shared vision of tackling the toughest challenges before us.”